O52E4_HUMAN
ID O52E4_HUMAN Reviewed; 312 AA.
AC Q8NGH9; Q6IFG0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 52E4;
DE AltName: Full=Olfactory receptor OR11-55;
GN Name=OR52E4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52E4";
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DR EMBL; AB065817; BAC06036.1; -; Genomic_DNA.
DR EMBL; BK004302; DAA04700.1; -; Genomic_DNA.
DR CCDS; CCDS31401.1; -.
DR RefSeq; NP_001005165.1; NM_001005165.1.
DR AlphaFoldDB; Q8NGH9; -.
DR SMR; Q8NGH9; -.
DR STRING; 9606.ENSP00000321426; -.
DR GlyGen; Q8NGH9; 1 site.
DR BioMuta; OR52E4; -.
DR DMDM; 38372697; -.
DR PaxDb; Q8NGH9; -.
DR PeptideAtlas; Q8NGH9; -.
DR PRIDE; Q8NGH9; -.
DR Antibodypedia; 57953; 53 antibodies from 15 providers.
DR DNASU; 390081; -.
DR Ensembl; ENST00000641726.1; ENSP00000493085.1; ENSG00000180974.5.
DR GeneID; 390081; -.
DR KEGG; hsa:390081; -.
DR MANE-Select; ENST00000641726.1; ENSP00000493085.1; NM_001005165.2; NP_001005165.1.
DR UCSC; uc010qzs.3; human.
DR CTD; 390081; -.
DR GeneCards; OR52E4; -.
DR HGNC; HGNC:15213; OR52E4.
DR HPA; ENSG00000180974; Tissue enhanced (brain).
DR neXtProt; NX_Q8NGH9; -.
DR PharmGKB; PA32405; -.
DR VEuPathDB; HostDB:ENSG00000180974; -.
DR eggNOG; ENOG502RNPB; Eukaryota.
DR GeneTree; ENSGT01050000244945; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGH9; -.
DR OMA; ETIHIWI; -.
DR OrthoDB; 886101at2759; -.
DR PhylomeDB; Q8NGH9; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGH9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390081; 13 hits in 672 CRISPR screens.
DR GeneWiki; OR52E4; -.
DR GenomeRNAi; 390081; -.
DR Pharos; Q8NGH9; Tdark.
DR PRO; PR:Q8NGH9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGH9; protein.
DR Bgee; ENSG00000180974; Expressed in placenta and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 52E4"
FT /id="PRO_0000150773"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 49
FT /note="F -> L (in dbSNP:rs16914094)"
FT /id="VAR_034335"
FT VARIANT 176
FT /note="V -> I (in dbSNP:rs4758168)"
FT /id="VAR_024147"
FT VARIANT 184
FT /note="R -> M (in dbSNP:rs4757986)"
FT /id="VAR_024148"
FT VARIANT 227
FT /note="F -> L (in dbSNP:rs11823828)"
FT /id="VAR_062082"
FT VARIANT 228
FT /note="R -> H (in dbSNP:rs4757987)"
FT /id="VAR_034336"
FT VARIANT 257
FT /note="F -> L (in dbSNP:rs11823842)"
FT /id="VAR_034337"
SQ SEQUENCE 312 AA; 35480 MW; EBB273B03A05149A CRC64;
MPSINDTHFY PPFFLLLGIP GLDTLHIWIS FPFCIVYLIA IVGNMTILFV IKTEHSLHQP
MFYFLAMLSM IDLGLSTSTI PKMLGIFWFN LQEISFGGCL LQMFFIHMFT GMETVLLVVM
AYDRFVAICN PLQYTMILTN KTISILASVV VGRNLVLVTP FVFLILRLPF CGHNIVPHTY
CEHRGLAGLA CAPIKINIIY GLMVISYIIV DVILIASSYV LILRAVFRLP SQDVRLKAFN
TCGSHVCVML CFYTPAFFSF MTHRFGQNIP HYIHILLANL YVVVPPALNP VIYGVRTKQI
REQIVKIFVQ KE
