O52E5_HUMAN
ID O52E5_HUMAN Reviewed; 327 AA.
AC Q8NH55;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2013, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Olfactory receptor 52E5;
GN Name=OR52E5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05782.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52E5";
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DR EMBL; AB065536; BAC05782.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q8NH55; -.
DR SMR; Q8NH55; -.
DR STRING; 9606.ENSP00000480583; -.
DR GlyGen; Q8NH55; 1 site.
DR BioMuta; OR52E5; -.
DR DMDM; 557952596; -.
DR PRIDE; Q8NH55; -.
DR Antibodypedia; 73008; 23 antibodies from 10 providers.
DR Ensembl; ENST00000610445.2; ENSP00000480583.1; ENSG00000277932.2.
DR MANE-Select; ENST00000610445.2; ENSP00000480583.1; NM_001005166.5; NP_001005166.3.
DR UCSC; uc057yiu.1; human.
DR GeneCards; OR52E5; -.
DR HGNC; HGNC:15214; OR52E5.
DR HPA; ENSG00000277932; Not detected.
DR neXtProt; NX_Q8NH55; -.
DR VEuPathDB; HostDB:ENSG00000277932; -.
DR eggNOG; ENOG502TDW4; Eukaryota.
DR GeneTree; ENSGT01050000244945; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH55; -.
DR OMA; MYTIHIC; -.
DR PathwayCommons; Q8NH55; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; Q8NH55; Tdark.
DR PRO; PR:Q8NH55; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH55; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..327
FT /note="Olfactory receptor 52E5"
FT /id="PRO_0000150774"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 165
FT /note="I -> T (in dbSNP:rs17234326)"
FT /id="VAR_034338"
FT VARIANT 209
FT /note="D -> G (in dbSNP:rs16926732)"
FT /id="VAR_034339"
FT VARIANT 234
FT /note="P -> L (in dbSNP:rs7106300)"
FT /id="VAR_034340"
SQ SEQUENCE 327 AA; 36851 MW; 3FA0D6A2EF981C0D CRC64;
MLHTNNTQFH PSTFLVVGVP GLEDVHVWIG FPFFAVYLTA LLGNIIILFV IQTEQSLHQP
MFYFLAMLAG TDLGLSTATI PKMLGIFWFN LGEIAFGACI TQMYTIHICT GLESVVLTVT
GIDRYIAICN PLRYSMILTN KVIAILGIVI IVRTLVFVTP FTFLILRLPF CGVRIIPHTY
CEHMGLAKLA CASINVIYGL IAFSVGYIDI SVIGFSYVQI LRAVFHLPAW DARPKALSTC
GSHVCVMLAF YLPALFSFMT HRFGHNIPHY IHILLANLYV VFPPALNSVI YGVKTKQIRE
QVLRILNPKS FWHFDPKRIF HNNSVRQ