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O52E5_HUMAN
ID   O52E5_HUMAN             Reviewed;         327 AA.
AC   Q8NH55;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2013, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Olfactory receptor 52E5;
GN   Name=OR52E5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05782.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52E5";
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DR   EMBL; AB065536; BAC05782.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q8NH55; -.
DR   SMR; Q8NH55; -.
DR   STRING; 9606.ENSP00000480583; -.
DR   GlyGen; Q8NH55; 1 site.
DR   BioMuta; OR52E5; -.
DR   DMDM; 557952596; -.
DR   PRIDE; Q8NH55; -.
DR   Antibodypedia; 73008; 23 antibodies from 10 providers.
DR   Ensembl; ENST00000610445.2; ENSP00000480583.1; ENSG00000277932.2.
DR   MANE-Select; ENST00000610445.2; ENSP00000480583.1; NM_001005166.5; NP_001005166.3.
DR   UCSC; uc057yiu.1; human.
DR   GeneCards; OR52E5; -.
DR   HGNC; HGNC:15214; OR52E5.
DR   HPA; ENSG00000277932; Not detected.
DR   neXtProt; NX_Q8NH55; -.
DR   VEuPathDB; HostDB:ENSG00000277932; -.
DR   eggNOG; ENOG502TDW4; Eukaryota.
DR   GeneTree; ENSGT01050000244945; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q8NH55; -.
DR   OMA; MYTIHIC; -.
DR   PathwayCommons; Q8NH55; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   Pharos; Q8NH55; Tdark.
DR   PRO; PR:Q8NH55; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH55; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Olfactory receptor 52E5"
FT                   /id="PRO_0000150774"
FT   TOPO_DOM        1..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..327
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..191
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         165
FT                   /note="I -> T (in dbSNP:rs17234326)"
FT                   /id="VAR_034338"
FT   VARIANT         209
FT                   /note="D -> G (in dbSNP:rs16926732)"
FT                   /id="VAR_034339"
FT   VARIANT         234
FT                   /note="P -> L (in dbSNP:rs7106300)"
FT                   /id="VAR_034340"
SQ   SEQUENCE   327 AA;  36851 MW;  3FA0D6A2EF981C0D CRC64;
     MLHTNNTQFH PSTFLVVGVP GLEDVHVWIG FPFFAVYLTA LLGNIIILFV IQTEQSLHQP
     MFYFLAMLAG TDLGLSTATI PKMLGIFWFN LGEIAFGACI TQMYTIHICT GLESVVLTVT
     GIDRYIAICN PLRYSMILTN KVIAILGIVI IVRTLVFVTP FTFLILRLPF CGVRIIPHTY
     CEHMGLAKLA CASINVIYGL IAFSVGYIDI SVIGFSYVQI LRAVFHLPAW DARPKALSTC
     GSHVCVMLAF YLPALFSFMT HRFGHNIPHY IHILLANLYV VFPPALNSVI YGVKTKQIRE
     QVLRILNPKS FWHFDPKRIF HNNSVRQ
 
 
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