O52E6_HUMAN
ID O52E6_HUMAN Reviewed; 313 AA.
AC Q96RD3; Q6IFF8;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Olfactory receptor 52E6;
DE AltName: Full=Olfactory receptor OR11-58;
GN Name=OR52E6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-287.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52E6";
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DR EMBL; AB065815; BAC06034.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68758.1; -; Genomic_DNA.
DR EMBL; AF399504; AAK94989.1; -; Genomic_DNA.
DR EMBL; BK004304; DAA04702.1; -; Genomic_DNA.
DR CCDS; CCDS53597.1; -.
DR RefSeq; NP_001005167.1; NM_001005167.1.
DR AlphaFoldDB; Q96RD3; -.
DR SMR; Q96RD3; -.
DR BioGRID; 133388; 1.
DR STRING; 9606.ENSP00000328878; -.
DR GlyGen; Q96RD3; 1 site.
DR iPTMnet; Q96RD3; -.
DR PhosphoSitePlus; Q96RD3; -.
DR BioMuta; OR52E6; -.
DR DMDM; 20532197; -.
DR PaxDb; Q96RD3; -.
DR PeptideAtlas; Q96RD3; -.
DR PRIDE; Q96RD3; -.
DR Antibodypedia; 57923; 62 antibodies from 16 providers.
DR DNASU; 390078; -.
DR Ensembl; ENST00000329322.5; ENSP00000328878.5; ENSG00000205409.3.
DR GeneID; 390078; -.
DR KEGG; hsa:390078; -.
DR MANE-Select; ENST00000329322.5; ENSP00000328878.5; NM_001005167.2; NP_001005167.1.
DR UCSC; uc010qzq.3; human.
DR CTD; 390078; -.
DR GeneCards; OR52E6; -.
DR HGNC; HGNC:15215; OR52E6.
DR HPA; ENSG00000205409; Not detected.
DR neXtProt; NX_Q96RD3; -.
DR PharmGKB; PA32407; -.
DR VEuPathDB; HostDB:ENSG00000205409; -.
DR eggNOG; ENOG502RYU0; Eukaryota.
DR GeneTree; ENSGT01050000244945; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q96RD3; -.
DR OrthoDB; 963485at2759; -.
DR PhylomeDB; Q96RD3; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q96RD3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390078; 9 hits in 658 CRISPR screens.
DR GeneWiki; OR52E6; -.
DR GenomeRNAi; 390078; -.
DR Pharos; Q96RD3; Tdark.
DR PRO; PR:Q96RD3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96RD3; protein.
DR Bgee; ENSG00000205409; Expressed in colonic epithelium and 2 other tissues.
DR ExpressionAtlas; Q96RD3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 52E6"
FT /id="PRO_0000150775"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 39
FT /note="I -> V (in dbSNP:rs4362173)"
FT /id="VAR_048066"
FT VARIANT 48
FT /note="F -> L (in dbSNP:rs10769272)"
FT /id="VAR_048067"
FT VARIANT 64
FT /note="C -> F (in dbSNP:rs4495918)"
FT /id="VAR_048068"
FT VARIANT 95
FT /note="S -> P (in dbSNP:rs4592451)"
FT /id="VAR_048069"
FT VARIANT 133
FT /note="W -> R (in dbSNP:rs10838719)"
FT /id="VAR_048070"
FT VARIANT 159
FT /note="I -> V (in dbSNP:rs4357719)"
FT /id="VAR_048071"
FT VARIANT 170
FT /note="F -> Y (in dbSNP:rs7943698)"
FT /id="VAR_048072"
FT VARIANT 199
FT /note="M -> R (in dbSNP:rs10742809)"
FT /id="VAR_048073"
SQ SEQUENCE 313 AA; 35524 MW; 6FC174DBDCB20BB3 CRC64;
MPIANDTQFH TSSFLLLGIP GLEDVHIWIG FPFFSVYLIA LLGNAAIFFV IQTEQSLHEP
MYYCLAMLDS IDLSLSTATI PKMLGIFWFN IKEISFGGYL SQMFFIHFFT VMESIVLVAM
AFDRYIAICK PLWYTMILTS KIISLIAGIA VLRSLYMVIP LVFLLLRLPF CGHRIIPHTY
CEHMGIARLA CASIKVNIMF GLGSISLLLL DVLLIILSHI RILYAVFCLP SWEARLKALN
TCGSHIGVIL AFSTPAFFSF FTHCFGHDIP QYIHIFLANL YVVVPPTLNP VIYGVRTKHI
RETVLRIFFK TDH
