O52E8_HUMAN
ID O52E8_HUMAN Reviewed; 317 AA.
AC Q6IFG1; B9EH38;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Olfactory receptor 52E8;
DE AltName: Full=Olfactory receptor OR11-54;
GN Name=OR52E8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52E8";
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DR EMBL; AC019088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137030; AAI37031.1; -; mRNA.
DR EMBL; BC137041; AAI37042.1; -; mRNA.
DR EMBL; BK004301; DAA04699.1; -; Genomic_DNA.
DR RefSeq; NP_001005168.1; NM_001005168.1.
DR AlphaFoldDB; Q6IFG1; -.
DR SMR; Q6IFG1; -.
DR STRING; 9606.ENSP00000444054; -.
DR GlyGen; Q6IFG1; 1 site.
DR iPTMnet; Q6IFG1; -.
DR PhosphoSitePlus; Q6IFG1; -.
DR BioMuta; OR52E8; -.
DR DMDM; 239938871; -.
DR PaxDb; Q6IFG1; -.
DR PeptideAtlas; Q6IFG1; -.
DR PRIDE; Q6IFG1; -.
DR Antibodypedia; 77126; 9 antibodies from 8 providers.
DR DNASU; 390079; -.
DR Ensembl; ENST00000537935.2; ENSP00000444054.2; ENSG00000183269.6.
DR GeneID; 390079; -.
DR KEGG; hsa:390079; -.
DR UCSC; uc010qzr.3; human.
DR CTD; 390079; -.
DR GeneCards; OR52E8; -.
DR HGNC; HGNC:15217; OR52E8.
DR HPA; ENSG00000183269; Not detected.
DR neXtProt; NX_Q6IFG1; -.
DR PharmGKB; PA32409; -.
DR VEuPathDB; HostDB:ENSG00000183269; -.
DR eggNOG; ENOG502RYU0; Eukaryota.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q6IFG1; -.
DR OMA; PQFIHIL; -.
DR OrthoDB; 963485at2759; -.
DR PhylomeDB; Q6IFG1; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q6IFG1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390079; 6 hits in 623 CRISPR screens.
DR GeneWiki; OR52E8; -.
DR GenomeRNAi; 390079; -.
DR Pharos; Q6IFG1; Tdark.
DR PRO; PR:Q6IFG1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6IFG1; protein.
DR ExpressionAtlas; Q6IFG1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 52E8"
FT /id="PRO_0000150776"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 103..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 317 AA; 35913 MW; E1A4A63025BFEA3E CRC64;
MAGRMSTSNH TQFHPSSFLL LGIPGLEDVH IWIGVPFFFV YLVALLGNTA LLFVIQTEQS
LHEPMYYFLA MLDSIDLGLS TATIPKMLGI FWFNTKEISF GGCLSHMFFI HFFTAMESIV
LVAMAFDRYI AICKPLRYTM ILTSKIISLI AGIAVLRSLY MVVPLVFLLL RLPFCGHRII
PHTYCEHMGI ARLACASIKV NIRFGLGNIS LLLLDVILII LSYVRILYAV FCLPSWEARL
KALNTCGSHI GVILAFFTPA FFSFLTHRFG HNIPQYIHII LANLYVVVPP ALNPVIYGVR
TKQIRERVLR IFLKTNH
