O52H1_HUMAN
ID O52H1_HUMAN Reviewed; 320 AA.
AC Q8NGJ2; B9EH26; Q6IF79;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 3.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 52H1;
DE AltName: Full=Olfactory receptor OR11-45;
GN Name=OR52H1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52H1";
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DR EMBL; AB065802; BAC06021.1; -; Genomic_DNA.
DR EMBL; BC136998; AAI36999.1; -; mRNA.
DR EMBL; BK004383; DAA04781.1; -; Genomic_DNA.
DR RefSeq; NP_001005289.1; NM_001005289.1.
DR AlphaFoldDB; Q8NGJ2; -.
DR SMR; Q8NGJ2; -.
DR STRING; 9606.ENSP00000326259; -.
DR GlyGen; Q8NGJ2; 2 sites.
DR iPTMnet; Q8NGJ2; -.
DR PhosphoSitePlus; Q8NGJ2; -.
DR BioMuta; OR52H1; -.
DR DMDM; 223590251; -.
DR PaxDb; Q8NGJ2; -.
DR PeptideAtlas; Q8NGJ2; -.
DR PRIDE; Q8NGJ2; -.
DR Antibodypedia; 66901; 69 antibodies from 17 providers.
DR DNASU; 390067; -.
DR Ensembl; ENST00000641796.2; ENSP00000493308.2; ENSG00000181616.10.
DR GeneID; 390067; -.
DR KEGG; hsa:390067; -.
DR UCSC; uc010qzh.2; human.
DR CTD; 390067; -.
DR GeneCards; OR52H1; -.
DR HGNC; HGNC:15218; OR52H1.
DR HPA; ENSG00000181616; Not detected.
DR neXtProt; NX_Q8NGJ2; -.
DR PharmGKB; PA32410; -.
DR VEuPathDB; HostDB:ENSG00000181616; -.
DR eggNOG; ENOG502QW9N; Eukaryota.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGJ2; -.
DR OrthoDB; 1013884at2759; -.
DR PhylomeDB; Q8NGJ2; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGJ2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390067; 9 hits in 675 CRISPR screens.
DR GeneWiki; OR52H1; -.
DR GenomeRNAi; 390067; -.
DR Pharos; Q8NGJ2; Tdark.
DR PRO; PR:Q8NGJ2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGJ2; protein.
DR Bgee; ENSG00000181616; Expressed in sural nerve and 4 other tissues.
DR ExpressionAtlas; Q8NGJ2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 52H1"
FT /id="PRO_0000150777"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 45
FT /note="V -> A (in dbSNP:rs56291963)"
FT /id="VAR_062083"
FT VARIANT 47
FT /note="V -> I (in dbSNP:rs2254076)"
FT /id="VAR_054361"
FT VARIANT 89
FT /note="A -> T (in dbSNP:rs10769054)"
FT /id="VAR_054362"
FT VARIANT 130
FT /note="H -> R (in dbSNP:rs1566275)"
FT /id="VAR_054363"
FT VARIANT 235
FT /note="G -> C (in dbSNP:rs1995157)"
FT /id="VAR_054364"
FT VARIANT 242
FT /note="C -> R (in dbSNP:rs1995158)"
FT /id="VAR_054365"
FT VARIANT 283
FT /note="M -> T (in dbSNP:rs7934354)"
FT /id="VAR_054366"
SQ SEQUENCE 320 AA; 35592 MW; 71E26A745498018D CRC64;
MPSASAMIIF NLSSYNPGPF ILVGIPGLEQ FHVWIGIPFC IIYIVAVVGN CILLYLIVVE
HSLHEPMFFF LSMLAMTDLI LSTAGVPKAL SIFWLGAREI TFPGCLTQMF FLHYNFVLDS
AILMAMAFDH YVAICSPLRY TTILTPKTII KSAMGISFRS FCIILPDVFL LTCLPFCRTR
IIPHTYCEHI GVAQLACADI SINFWYGFCV PIMTVISDVI LIAVSYAHIL CAVFGLPSQD
ACQKALGTCG SHVCVILMFY TPAFFSILAH RFGHNVSRTF HIMFANLYIV IPPALNPMVY
GVKTKQIRDK VILLFSKGTG
