ID   O52I1_HUMAN             Reviewed;         324 AA.
AC   Q8NGK6; Q6IF91;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Olfactory receptor 52I1;
DE   AltName: Full=Olfactory receptor OR11-13;
GN   Name=OR52I1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC06007.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52I1";
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DR   EMBL; AB065788; BAC06007.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BK004371; DAA04769.1; -; Genomic_DNA.
DR   CCDS; CCDS59223.1; -.
DR   RefSeq; NP_001005169.1; NM_001005169.1.
DR   AlphaFoldDB; Q8NGK6; -.
DR   SMR; Q8NGK6; -.
DR   BioGRID; 133367; 5.
DR   IntAct; Q8NGK6; 1.
DR   STRING; 9606.ENSP00000436453; -.
DR   GlyGen; Q8NGK6; 1 site.
DR   iPTMnet; Q8NGK6; -.
DR   PhosphoSitePlus; Q8NGK6; -.
DR   BioMuta; OR52I1; -.
DR   DMDM; 38372717; -.
DR   PaxDb; Q8NGK6; -.
DR   PRIDE; Q8NGK6; -.
DR   Antibodypedia; 67157; 65 antibodies from 17 providers.
DR   DNASU; 390037; -.
DR   Ensembl; ENST00000530443.4; ENSP00000436453.1; ENSG00000232268.7.
DR   GeneID; 390037; -.
DR   KEGG; hsa:390037; -.
DR   MANE-Select; ENST00000530443.4; ENSP00000436453.1; NM_001005169.1; NP_001005169.1.
DR   UCSC; uc010qyi.2; human.
DR   CTD; 390037; -.
DR   GeneCards; OR52I1; -.
DR   HGNC; HGNC:15220; OR52I1.
DR   HPA; ENSG00000232268; Tissue enriched (brain).
DR   neXtProt; NX_Q8NGK6; -.
DR   OpenTargets; ENSG00000232268; -.
DR   PharmGKB; PA32412; -.
DR   VEuPathDB; HostDB:ENSG00000232268; -.
DR   eggNOG; ENOG502SX3E; Eukaryota.
DR   GeneTree; ENSGT01050000244932; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q8NGK6; -.
DR   OMA; FCGSHMV; -.
DR   OrthoDB; 818853at2759; -.
DR   PhylomeDB; Q8NGK6; -.
DR   PathwayCommons; Q8NGK6; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390037; 5 hits in 608 CRISPR screens.
DR   GeneWiki; OR52I1; -.
DR   GenomeRNAi; 390037; -.
DR   Pharos; Q8NGK6; Tdark.
DR   PRO; PR:Q8NGK6; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGK6; protein.
DR   Bgee; ENSG00000232268; Expressed in cortical plate and 5 other tissues.
DR   ExpressionAtlas; Q8NGK6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..324
FT                   /note="Olfactory receptor 52I1"
FT                   /id="PRO_0000150778"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..58
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..200
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..241
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..278
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        300..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        101..193
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         41
FT                   /note="T -> I (in dbSNP:rs2010722)"
FT                   /id="VAR_034342"
SQ   SEQUENCE   324 AA;  35386 MW;  460E0FCF43844960 CRC64;
     MLGPAYNHTM ETPASFLLVG IPGLQSSHLW LAISLSAMYI TALLGNTLIV TAIWMDSTRH
     EPMYCFLCVL AAVDIVMASS VVPKMVSIFC SGDSSISFSA CFTQMFFVHL ATAVETGLLL
     TMAFDRYVAI CKPLHYKRIL TPQVMLGMSM AVTIRAVTFM TPLSWMMNHL PFCGSNVVVH
     SYCKHIALAR LACADPVPSS LYSLIGSSLM VGSDVAFIAA SYILILRAVF DLSSKTAQLK
     ALSTCGSHVG VMALYYLPGM ASIYAAWLGQ DIVPLHTQVL LADLYVIIPA TLNPIIYGMR
     TKQLLEGIWS YLMHFLFDHS NLGS