O52I2_HUMAN
ID O52I2_HUMAN Reviewed; 350 AA.
AC Q8NH67; B2RNJ5; B9EKV8; Q6IFJ8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 3.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 52I2;
DE AltName: Full=Olfactory receptor OR11-12;
GN Name=OR52I2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-74.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-27 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05770.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52I2";
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DR EMBL; AB065522; BAC05770.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC136921; AAI36922.1; -; mRNA.
DR EMBL; BC151144; AAI51145.1; -; mRNA.
DR EMBL; BK004264; DAA04662.1; -; Genomic_DNA.
DR CCDS; CCDS31355.1; -.
DR RefSeq; NP_001005170.1; NM_001005170.2.
DR AlphaFoldDB; Q8NH67; -.
DR SMR; Q8NH67; -.
DR STRING; 9606.ENSP00000308764; -.
DR GlyGen; Q8NH67; 1 site.
DR iPTMnet; Q8NH67; -.
DR PhosphoSitePlus; Q8NH67; -.
DR BioMuta; OR52I2; -.
DR DMDM; 218512129; -.
DR EPD; Q8NH67; -.
DR PaxDb; Q8NH67; -.
DR PeptideAtlas; Q8NH67; -.
DR PRIDE; Q8NH67; -.
DR TopDownProteomics; Q8NH67; -.
DR Antibodypedia; 57459; 83 antibodies from 19 providers.
DR DNASU; 143502; -.
DR GeneID; 143502; -.
DR KEGG; hsa:143502; -.
DR UCSC; uc010qyh.2; human.
DR CTD; 143502; -.
DR DisGeNET; 143502; -.
DR GeneCards; OR52I2; -.
DR HGNC; HGNC:15221; OR52I2.
DR HPA; ENSG00000226288; Not detected.
DR neXtProt; NX_Q8NH67; -.
DR PharmGKB; PA32413; -.
DR VEuPathDB; HostDB:ENSG00000226288; -.
DR eggNOG; ENOG502SX3E; Eukaryota.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH67; -.
DR OrthoDB; 818853at2759; -.
DR PhylomeDB; Q8NH67; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NH67; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 143502; 14 hits in 608 CRISPR screens.
DR GeneWiki; OR52I2; -.
DR GenomeRNAi; 143502; -.
DR Pharos; Q8NH67; Tdark.
DR PRO; PR:Q8NH67; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH67; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..350
FT /note="Olfactory receptor 52I2"
FT /id="PRO_0000150779"
FT TOPO_DOM 1..55
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..129
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..304
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..350
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..219
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 25
FT /note="L -> P (in dbSNP:rs7128702)"
FT /id="VAR_048082"
FT VARIANT 74
FT /note="I -> L (in dbSNP:rs12793957)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_048083"
FT VARIANT 167
FT /note="T -> M (in dbSNP:rs1847632)"
FT /id="VAR_048084"
FT VARIANT 178
FT /note="I -> V (in dbSNP:rs7947426)"
FT /id="VAR_048085"
FT VARIANT 183
FT /note="I -> V (in dbSNP:rs7947432)"
FT /id="VAR_048086"
SQ SEQUENCE 350 AA; 38353 MW; 66102900C9929875 CRC64;
MCQQILRDCI LLIHHLCINR KKVSLVMLGP AYNHTMETPA SFLLVGIPGL QSSHLWLAIS
LSAMYIIALL GNTIIVTAIW MDSTRHEPMY CFLCVLAAVD IVMASSVVPK MVSIFCSGDS
SISFSACFTQ MFFVHLATAV ETGLLLTMAF DRYVAICKPL HYKRILTPQV MLGMSMAITI
RAIIAITPLS WMVSHLPFCG SNVVVHSYCE HIALARLACA DPVPSSLYSL IGSSLMVGSD
VAFIAASYIL ILKAVFGLSS KTAQLKALST CGSHVGVMAL YYLPGMASIY AAWLGQDVVP
LHTQVLLADL YVIIPATLNP IIYGMRTKQL RERIWSYLMH VLFDHSNLGS
