O52J3_HUMAN
ID O52J3_HUMAN Reviewed; 311 AA.
AC Q8NH60; Q6IFE4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 52J3;
DE AltName: Full=Olfactory receptor OR11-32;
GN Name=OR52J3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-77; ILE-128 AND
RP LEU-141.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS ALA-77; ILE-128
RP AND LEU-141.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION, AND VARIANTS ALA-77; ILE-128 AND LEU-141.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52J3";
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DR EMBL; AB065530; BAC05777.1; -; Genomic_DNA.
DR EMBL; AC113331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68813.1; -; Genomic_DNA.
DR EMBL; BK004318; DAA04716.1; -; Genomic_DNA.
DR CCDS; CCDS31370.1; -.
DR RefSeq; NP_001001916.2; NM_001001916.2.
DR AlphaFoldDB; Q8NH60; -.
DR SMR; Q8NH60; -.
DR STRING; 9606.ENSP00000369728; -.
DR GlyGen; Q8NH60; 1 site.
DR iPTMnet; Q8NH60; -.
DR PhosphoSitePlus; Q8NH60; -.
DR BioMuta; OR52J3; -.
DR DMDM; 296439249; -.
DR PaxDb; Q8NH60; -.
DR PeptideAtlas; Q8NH60; -.
DR PRIDE; Q8NH60; -.
DR Antibodypedia; 66777; 65 antibodies from 15 providers.
DR DNASU; 119679; -.
DR Ensembl; ENST00000380370.1; ENSP00000369728.1; ENSG00000205495.1.
DR GeneID; 119679; -.
DR KEGG; hsa:119679; -.
DR MANE-Select; ENST00000380370.1; ENSP00000369728.1; NM_001001916.2; NP_001001916.2.
DR UCSC; uc010qyv.2; human.
DR CTD; 119679; -.
DR DisGeNET; 119679; -.
DR GeneCards; OR52J3; -.
DR HGNC; HGNC:14799; OR52J3.
DR HPA; ENSG00000205495; Not detected.
DR neXtProt; NX_Q8NH60; -.
DR OpenTargets; ENSG00000205495; -.
DR PharmGKB; PA32416; -.
DR VEuPathDB; HostDB:ENSG00000205495; -.
DR eggNOG; ENOG502RNPB; Eukaryota.
DR GeneTree; ENSGT01050000244945; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH60; -.
DR OMA; FGHQIPG; -.
DR OrthoDB; 914661at2759; -.
DR PhylomeDB; Q8NH60; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NH60; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH60; -.
DR BioGRID-ORCS; 119679; 9 hits in 667 CRISPR screens.
DR GeneWiki; OR52J3; -.
DR GenomeRNAi; 119679; -.
DR Pharos; Q8NH60; Tdark.
DR PRO; PR:Q8NH60; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH60; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 52J3"
FT /id="PRO_0000150780"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 77
FT /note="T -> A (in dbSNP:rs2500016)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3"
FT /id="VAR_034343"
FT VARIANT 128
FT /note="V -> I (in dbSNP:rs2500017)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3"
FT /id="VAR_034344"
FT VARIANT 141
FT /note="Q -> L (in dbSNP:rs2500018)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3"
FT /id="VAR_034345"
FT VARIANT 226
FT /note="V -> I (in dbSNP:rs17350764)"
FT /id="VAR_034346"
SQ SEQUENCE 311 AA; 35091 MW; 8830E9F7A54B3D33 CRC64;
MFYHNKSIFH PVTFFLIGIP GLEDFHMWIS GPFCSVYLVA LLGNATILLV IKVEQTLREP
MFYFLAILST IDLALSTTSV PRMLGIFWFD AHEINYGACV AQMFLIHAFT GMEAEVLLAM
AFDRYVAVCA PLHYATILTS QVLVGISMCI VIRPVLLTLP MVYLIYRLPF CQAHIIAHSY
CEHMGIAKLS CGNIRINGIY GLFVVSFFVL NLVLIGISYV YILRAVFRLP SHDAQLKALS
TCGAHVGVIC VFYIPSVFSF LTHRFGHQIP GYIHILVANL YLIIPPSLNP IIYGVRTKQI
RERVLYVFTK K
