O52K1_HUMAN
ID O52K1_HUMAN Reviewed; 314 AA.
AC Q8NGK4; B9EH54; Q6IFK5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 52K1;
DE AltName: Full=Olfactory receptor OR11-8;
GN Name=OR52K1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-52 AND TRP-153.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-52 AND TRP-153.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION, AND VARIANTS ARG-52 AND TRP-153.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52K1";
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DR EMBL; AB065790; BAC06009.1; -; Genomic_DNA.
DR EMBL; AC010930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137056; AAI37057.1; -; mRNA.
DR EMBL; BC137059; AAI37060.1; -; mRNA.
DR EMBL; BK004257; DAA04655.1; -; Genomic_DNA.
DR CCDS; CCDS31352.1; -.
DR RefSeq; NP_001005171.2; NM_001005171.2.
DR AlphaFoldDB; Q8NGK4; -.
DR SMR; Q8NGK4; -.
DR STRING; 9606.ENSP00000302422; -.
DR GlyGen; Q8NGK4; 1 site.
DR iPTMnet; Q8NGK4; -.
DR PhosphoSitePlus; Q8NGK4; -.
DR BioMuta; OR52K1; -.
DR DMDM; 296439250; -.
DR MassIVE; Q8NGK4; -.
DR PaxDb; Q8NGK4; -.
DR PeptideAtlas; Q8NGK4; -.
DR PRIDE; Q8NGK4; -.
DR ProteomicsDB; 73540; -.
DR Antibodypedia; 57455; 42 antibodies from 15 providers.
DR DNASU; 390036; -.
DR Ensembl; ENST00000641528.1; ENSP00000493011.1; ENSG00000196778.4.
DR GeneID; 390036; -.
DR KEGG; hsa:390036; -.
DR MANE-Select; ENST00000641528.1; ENSP00000493011.1; NM_001005171.3; NP_001005171.2.
DR UCSC; uc001lza.2; human.
DR CTD; 390036; -.
DR GeneCards; OR52K1; -.
DR HGNC; HGNC:15222; OR52K1.
DR HPA; ENSG00000196778; Tissue enhanced (bone).
DR neXtProt; NX_Q8NGK4; -.
DR OpenTargets; ENSG00000196778; -.
DR PharmGKB; PA32417; -.
DR VEuPathDB; HostDB:ENSG00000196778; -.
DR eggNOG; ENOG502SHN8; Eukaryota.
DR GeneTree; ENSGT01050000244847; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGK4; -.
DR OMA; KQIRDYM; -.
DR OrthoDB; 995051at2759; -.
DR PhylomeDB; Q8NGK4; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGK4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390036; 6 hits in 667 CRISPR screens.
DR GeneWiki; OR52K1; -.
DR GenomeRNAi; 390036; -.
DR Pharos; Q8NGK4; Tdark.
DR PRO; PR:Q8NGK4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGK4; protein.
DR Bgee; ENSG00000196778; Expressed in monocyte and 6 other tissues.
DR ExpressionAtlas; Q8NGK4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 52K1"
FT /id="PRO_0000150781"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 52
FT /note="Q -> R (in dbSNP:rs96489)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_060038"
FT VARIANT 153
FT /note="R -> W (in dbSNP:rs331510)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_060039"
SQ SEQUENCE 314 AA; 35231 MW; 4717C5B7F18AC68E CRC64;
MLPSNITSTH PAVFLLVGIP GLEHLHAWIS IPFCFAYTLA LLGNCTLLFI IQADAALHEP
MYLFLAMLAT IDLVLSSTTL PKMLAIFWFR DQEINFFACL VQMFFLHSFS IMESAVLLAM
AFDRYVAICK PLHYTTVLTG SLITKIGMAA VARAVTLMTP LPFLLRRFHY CRGPVIAHCY
CEHMAVVRLA CGDTSFNNIY GIAVAMFIVV LDLLFVILSY VFILQAVLQL ASQEARYKAF
GTCVSHIGAI LSTYTPVVIS SVMHRVARHA APRVHILLAI FYLLFPPMVN PIIYGVKTKQ
IREYVLSLFQ RKNM
