O52K2_HUMAN
ID O52K2_HUMAN Reviewed; 314 AA.
AC Q8NGK3; A8MUY8; B2RP35; Q6IFK4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 52K2;
DE AltName: Full=Olfactory receptor OR11-7;
GN Name=OR52K2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT HIS-236.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52K2";
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DR EMBL; AB065791; BAC06010.1; -; Genomic_DNA.
DR EMBL; AC010930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68843.1; -; Genomic_DNA.
DR EMBL; BC137247; AAI37248.1; -; mRNA.
DR EMBL; BC137248; AAI37249.1; -; mRNA.
DR EMBL; BK004258; DAA04656.1; -; Genomic_DNA.
DR CCDS; CCDS31351.1; -.
DR RefSeq; NP_001005172.2; NM_001005172.2.
DR AlphaFoldDB; Q8NGK3; -.
DR SMR; Q8NGK3; -.
DR BioGRID; 125662; 6.
DR STRING; 9606.ENSP00000318956; -.
DR GlyGen; Q8NGK3; 1 site.
DR BioMuta; OR52K2; -.
DR DMDM; 218511725; -.
DR MassIVE; Q8NGK3; -.
DR PaxDb; Q8NGK3; -.
DR PeptideAtlas; Q8NGK3; -.
DR PRIDE; Q8NGK3; -.
DR Antibodypedia; 57453; 16 antibodies from 10 providers.
DR DNASU; 119774; -.
DR Ensembl; ENST00000325719.4; ENSP00000318956.4; ENSG00000181963.5.
DR GeneID; 119774; -.
DR KEGG; hsa:119774; -.
DR MANE-Select; ENST00000325719.4; ENSP00000318956.4; NM_001005172.2; NP_001005172.2.
DR UCSC; uc001lyz.2; human.
DR CTD; 119774; -.
DR DisGeNET; 119774; -.
DR GeneCards; OR52K2; -.
DR HGNC; HGNC:15223; OR52K2.
DR HPA; ENSG00000181963; Not detected.
DR neXtProt; NX_Q8NGK3; -.
DR OpenTargets; ENSG00000181963; -.
DR PharmGKB; PA32418; -.
DR VEuPathDB; HostDB:ENSG00000181963; -.
DR eggNOG; ENOG502SHN8; Eukaryota.
DR GeneTree; ENSGT01050000244847; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGK3; -.
DR OMA; RVIAHCY; -.
DR OrthoDB; 999758at2759; -.
DR PhylomeDB; Q8NGK3; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGK3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 119774; 7 hits in 633 CRISPR screens.
DR ChiTaRS; OR52K2; human.
DR GeneWiki; OR52K2; -.
DR GenomeRNAi; 119774; -.
DR Pharos; Q8NGK3; Tdark.
DR PRO; PR:Q8NGK3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGK3; protein.
DR Bgee; ENSG00000181963; Expressed in monocyte and 5 other tissues.
DR ExpressionAtlas; Q8NGK3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 52K2"
FT /id="PRO_0000150782"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 124
FT /note="R -> C (in dbSNP:rs11032296)"
FT /id="VAR_034347"
FT VARIANT 236
FT /note="R -> H (in dbSNP:rs331537)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_047827"
FT VARIANT 302
FT /note="R -> C (in dbSNP:rs7934336)"
FT /id="VAR_034348"
SQ SEQUENCE 314 AA; 34926 MW; CCA5A033E904A0B6 CRC64;
MSASNITLTH PTAFLLVGIP GLEHLHIWIS IPFCLAYTLA LLGNCTLLLI IQADAALHEP
MYLFLAMLAA IDLVLSSSAL PKMLAIFWFR DREINFFACL AQMFFLHSFS IMESAVLLAM
AFDRYVAICK PLHYTKVLTG SLITKIGMAA VARAVTLMTP LPFLLRCFHY CRGPVIAHCY
CEHMAVVRLA CGDTSFNNIY GIAVAMFIVV LDLLLVILSY IFILQAVLLL ASQEARYKAF
GTCVSHIGAI LAFYTTVVIS SVMHRVARHA APHVHILLAN FYLLFPPMVN PIIYGVKTKQ
IRESILGVFP RKDM
