O52L1_HUMAN
ID O52L1_HUMAN Reviewed; 329 AA.
AC Q8NGH7; B2RPA6; Q6IFK9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 4.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 52L1;
DE AltName: Full=Olfactory receptor OR11-50;
GN Name=OR52L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-140; ARG-161; THR-183
RP AND ARG-297.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-88; ARG-140;
RP ARG-161; THR-183 AND ARG-297.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION, AND VARIANTS ARG-140; ARG-161; THR-183 AND ARG-297.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q8NGH7; Q15699: ALX1; NbExp=3; IntAct=EBI-13330637, EBI-750671;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52L1";
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DR EMBL; AB065819; BAC06038.1; -; Genomic_DNA.
DR EMBL; AC025016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC111177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137343; AAI37344.1; -; mRNA.
DR EMBL; BK004253; DAA04651.1; -; Genomic_DNA.
DR CCDS; CCDS44529.1; -.
DR RefSeq; NP_001005173.3; NM_001005173.3.
DR AlphaFoldDB; Q8NGH7; -.
DR SMR; Q8NGH7; -.
DR BioGRID; 130790; 2.
DR IntAct; Q8NGH7; 1.
DR STRING; 9606.ENSP00000330338; -.
DR GlyGen; Q8NGH7; 1 site.
DR BioMuta; OR52L1; -.
DR DMDM; 296439491; -.
DR PaxDb; Q8NGH7; -.
DR PeptideAtlas; Q8NGH7; -.
DR PRIDE; Q8NGH7; -.
DR Antibodypedia; 67196; 60 antibodies from 15 providers.
DR DNASU; 338751; -.
DR Ensembl; ENST00000332249.4; ENSP00000330338.4; ENSG00000183313.4.
DR GeneID; 338751; -.
DR KEGG; hsa:338751; -.
DR UCSC; uc001mcd.2; human.
DR CTD; 338751; -.
DR GeneCards; OR52L1; -.
DR HGNC; HGNC:14785; OR52L1.
DR HPA; ENSG00000183313; Not detected.
DR neXtProt; NX_Q8NGH7; -.
DR PharmGKB; PA32420; -.
DR VEuPathDB; HostDB:ENSG00000183313; -.
DR eggNOG; ENOG502QV28; Eukaryota.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGH7; -.
DR OrthoDB; 1009251at2759; -.
DR PhylomeDB; Q8NGH7; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGH7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGH7; -.
DR BioGRID-ORCS; 338751; 8 hits in 664 CRISPR screens.
DR GeneWiki; OR52L1; -.
DR GenomeRNAi; 338751; -.
DR Pharos; Q8NGH7; Tdark.
DR PRO; PR:Q8NGH7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGH7; protein.
DR Bgee; ENSG00000183313; Expressed in ventricular zone and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..329
FT /note="Olfactory receptor 52L1"
FT /id="PRO_0000150783"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..291
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 115..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 88
FT /note="D -> N (in dbSNP:rs4501959)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055078"
FT VARIANT 140
FT /note="C -> R (in dbSNP:rs4436525)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_055079"
FT VARIANT 161
FT /note="C -> R (in dbSNP:rs4436524)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_055080"
FT VARIANT 183
FT /note="K -> T (in dbSNP:rs4354673)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_055081"
FT VARIANT 297
FT /note="W -> R (in dbSNP:rs4237768)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_055082"
SQ SEQUENCE 329 AA; 36221 MW; B3EE384D7B548940 CRC64;
MTLVSFFSFL SKPLIMLLSN SSWRLSQPSF LLVGIPGLEE SQHWIALPLG ILYLLALVGN
VTILFIIWMD PSLHQSMYLF LSMLAAIDLV LASSTAPKAL AVLLVHAHEI GYIVCLIQMF
FIHAFSSMES GVLVAMALDC YVAICHPLHH STILHPGVIG CIGMVVLVRG LLLLIPFPIL
LGKLIFCQAT IIGHAYCEHM AVVKLACSET TVNRAYGLTM ALLVIGLDVL AIGVSYAHIL
QAVLKVPGSE ARLKAFSTCG SHICVILVFY VPGIFSFLTH RFGHHVPHHV HVLLATWYLL
MPPALNPLVY GVKTQQIRQR VLRVFTQKD
