O52L2_HUMAN
ID O52L2_HUMAN Reviewed; 319 AA.
AC Q8NGH6; Q6IFK8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 3.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Putative olfactory receptor 52L2;
DE AltName: Full=Olfactory receptor OR11-74;
GN Name=OR52L2P; Synonyms=OR52L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52L2P";
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DR EMBL; AB065820; BAC06039.1; -; Genomic_DNA.
DR EMBL; BK004254; DAA04652.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8NGH6; -.
DR SMR; Q8NGH6; -.
DR GlyGen; Q8NGH6; 1 site.
DR BioMuta; HGNC:14788; -.
DR DMDM; 218512127; -.
DR PeptideAtlas; Q8NGH6; -.
DR PRIDE; Q8NGH6; -.
DR ProteomicsDB; 73513; -.
DR GeneCards; OR52L2P; -.
DR HGNC; HGNC:14788; OR52L2P.
DR neXtProt; NX_Q8NGH6; -.
DR InParanoid; Q8NGH6; -.
DR PhylomeDB; Q8NGH6; -.
DR PathwayCommons; Q8NGH6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; Q8NGH6; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8NGH6; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Putative olfactory receptor 52L2"
FT /id="PRO_0000150784"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..291
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 115..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 319 AA; 35227 MW; E388732098F87297 CRC64;
MNLDSFFSFL LKSLIMALSN SSWRLPQPSF FLVGIPGLEE SQHWIALPLG ILYLLALVGN
VTILFIIWMD PSLHQSMYLF LSMLAAIDLV VASSTAPKAL AVLLVRAQEI GYTVCLIQMF
FTHAFSSMES GVLVAMALDR YVAICHPLHH STILHPGVIG HIGMVVLVRG LLLLIPFLIL
LRKLIFCQAT IIGHAYCEHM AVVKLACSET TVNRAYGLTV ALLVVGLDVL AIGVSYAHIL
QAVLKVPGNE ARLKAFSTCG SHVCVILVFY IPGMFSFLTH RFGHHVPHHV HVLLAILYRL
VPPALNPLVY RVKTQKIHQ
