O52M1_HUMAN
ID O52M1_HUMAN Reviewed; 317 AA.
AC Q8NGK5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Olfactory receptor 52M1;
DE AltName: Full=Olfactory receptor OR11-11;
GN Name=OR52M1; Synonyms=OR52M1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52M1";
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DR EMBL; AB065789; BAC06008.1; -; Genomic_DNA.
DR EMBL; BK004372; DAA04770.1; -; Genomic_DNA.
DR CCDS; CCDS31353.1; -.
DR RefSeq; NP_001004137.1; NM_001004137.1.
DR AlphaFoldDB; Q8NGK5; -.
DR SMR; Q8NGK5; -.
DR STRING; 9606.ENSP00000353343; -.
DR iPTMnet; Q8NGK5; -.
DR PhosphoSitePlus; Q8NGK5; -.
DR BioMuta; OR52M1; -.
DR DMDM; 74762580; -.
DR PaxDb; Q8NGK5; -.
DR PeptideAtlas; Q8NGK5; -.
DR PRIDE; Q8NGK5; -.
DR Antibodypedia; 67143; 13 antibodies from 10 providers.
DR DNASU; 119772; -.
DR Ensembl; ENST00000360213.1; ENSP00000353343.1; ENSG00000197790.1.
DR GeneID; 119772; -.
DR KEGG; hsa:119772; -.
DR MANE-Select; ENST00000360213.1; ENSP00000353343.1; NM_001004137.1; NP_001004137.1.
DR UCSC; uc010qyf.2; human.
DR CTD; 119772; -.
DR GeneCards; OR52M1; -.
DR HGNC; HGNC:15225; OR52M1.
DR HPA; ENSG00000197790; Not detected.
DR neXtProt; NX_Q8NGK5; -.
DR OpenTargets; ENSG00000197790; -.
DR PharmGKB; PA32422; -.
DR VEuPathDB; HostDB:ENSG00000197790; -.
DR eggNOG; ENOG502QTXQ; Eukaryota.
DR GeneTree; ENSGT01050000244847; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGK5; -.
DR OMA; CLGQMFL; -.
DR OrthoDB; 947849at2759; -.
DR PhylomeDB; Q8NGK5; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGK5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGK5; -.
DR BioGRID-ORCS; 119772; 12 hits in 675 CRISPR screens.
DR GeneWiki; OR52M1; -.
DR GenomeRNAi; 119772; -.
DR Pharos; Q8NGK5; Tdark.
DR PRO; PR:Q8NGK5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGK5; protein.
DR Bgee; ENSG00000197790; Expressed in ganglionic eminence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 52M1"
FT /id="PRO_0000150785"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 99..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 9
FT /note="S -> L (in dbSNP:rs7112010)"
FT /id="VAR_034349"
FT VARIANT 305
FT /note="S -> R (in dbSNP:rs2657167)"
FT /id="VAR_034350"
SQ SEQUENCE 317 AA; 35037 MW; B09AD144D01F104F CRC64;
MLTFHNVCSV PSSFWLTGIP GLESLHVWLS IPFGSMYLVA VVGNVTILAV VKIERSLHQP
MYFFLCMLAA IDLVLSTSTI PKLLGIFWFG ACDIGLDACL GQMFLIHCFA TVESGIFLAM
AFDRYVAICN PLRHSMVLTY TVVGRLGLVS LLRGVLYIGP LPLMIRLRLP LYKTHVISHS
YCEHMAVVAL TCGDSRVNNV YGLSIGFLVL ILDSVAIAAS YVMIFRAVMG LATPEARLKT
LGTCASHLCA ILIFYVPIAV SSLIHRFGQC VPPPVHTLLA NFYLLIPPIL NPIVYAVRTK
QIRESLLQIP RIEMKIR
