O52N1_HUMAN
ID O52N1_HUMAN Reviewed; 320 AA.
AC Q8NH53; Q6IFF6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 52N1;
DE AltName: Full=Olfactory receptor OR11-61;
GN Name=OR52N1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52N1";
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DR EMBL; AB065538; BAC05784.1; -; Genomic_DNA.
DR EMBL; BK004306; DAA04704.1; -; Genomic_DNA.
DR CCDS; CCDS31398.1; -.
DR RefSeq; NP_001001913.1; NM_001001913.1.
DR AlphaFoldDB; Q8NH53; -.
DR SMR; Q8NH53; -.
DR BioGRID; 122676; 1.
DR STRING; 9606.ENSP00000322823; -.
DR GlyGen; Q8NH53; 1 site.
DR iPTMnet; Q8NH53; -.
DR PhosphoSitePlus; Q8NH53; -.
DR BioMuta; OR52N1; -.
DR DMDM; 38372811; -.
DR PaxDb; Q8NH53; -.
DR PRIDE; Q8NH53; -.
DR Antibodypedia; 57908; 62 antibodies from 18 providers.
DR DNASU; 79473; -.
DR Ensembl; ENST00000641645.1; ENSP00000493272.1; ENSG00000181001.3.
DR GeneID; 79473; -.
DR KEGG; hsa:79473; -.
DR MANE-Select; ENST00000641645.1; ENSP00000493272.1; NM_001001913.2; NP_001001913.1.
DR UCSC; uc010qzo.2; human.
DR CTD; 79473; -.
DR GeneCards; OR52N1; -.
DR HGNC; HGNC:14853; OR52N1.
DR HPA; ENSG00000181001; Not detected.
DR neXtProt; NX_Q8NH53; -.
DR OpenTargets; ENSG00000181001; -.
DR PharmGKB; PA32425; -.
DR VEuPathDB; HostDB:ENSG00000181001; -.
DR eggNOG; ENOG502QV28; Eukaryota.
DR GeneTree; ENSGT01050000244847; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH53; -.
DR OMA; IRFFLKG; -.
DR OrthoDB; 884779at2759; -.
DR PhylomeDB; Q8NH53; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NH53; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79473; 8 hits in 640 CRISPR screens.
DR GeneWiki; OR52N1; -.
DR GenomeRNAi; 79473; -.
DR Pharos; Q8NH53; Tdark.
DR PRO; PR:Q8NH53; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH53; protein.
DR Bgee; ENSG00000181001; Expressed in lower esophagus mucosa and 20 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 52N1"
FT /id="PRO_0000150786"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 79
FT /note="T -> N (in dbSNP:rs12365487)"
FT /id="VAR_053335"
FT VARIANT 101
FT /note="A -> T (in dbSNP:rs10742787)"
FT /id="VAR_053336"
FT VARIANT 125
FT /note="C -> Y (in dbSNP:rs10769224)"
FT /id="VAR_053337"
FT VARIANT 167
FT /note="R -> C (in dbSNP:rs7948009)"
FT /id="VAR_024149"
FT VARIANT 247
FT /note="F -> I (in dbSNP:rs7934670)"
FT /id="VAR_034351"
SQ SEQUENCE 320 AA; 35785 MW; 37718814BE6B6D2E CRC64;
MSFLNGTSLT PASFILNGIP GLEDVHLWIS FPLCTMYSIA ITGNFGLMYL IYCDEALHRP
MYVFLALLSF TDVLMCTSTL PNTLFILWFN LKEIDFKACL AQMFFVHTFT GMESGVLMLM
ALDHCVAICF PLRYATILTN SVIAKAGFLT FLRGVMLVIP STFLTKRLPY CKGNVIPHTY
CDHMSVAKIS CGNVRVNAIY GLIVALLIGG FDILCITISY TMILQAVVSL SSADARQKAF
STCTAHFCAI VLTYVPAFFT FFTHHFGGHT IPLHIHIIMA NLYLLMPPTM NPIVYGVKTR
QVRESVIRFF LKGKDNSHNF
