O52N2_HUMAN
ID O52N2_HUMAN Reviewed; 321 AA.
AC Q8NGI0; B9EIL8; Q6IFF9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 52N2;
DE AltName: Full=Olfactory receptor OR11-57;
GN Name=OR52N2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ALA-249 AND ARG-264.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52N2";
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DR EMBL; AB065816; BAC06035.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68759.1; -; Genomic_DNA.
DR EMBL; BC140732; AAI40733.1; -; mRNA.
DR EMBL; BK004303; DAA04701.1; -; Genomic_DNA.
DR CCDS; CCDS31399.1; -.
DR RefSeq; NP_001005174.1; NM_001005174.1.
DR RefSeq; XP_011518392.1; XM_011520090.2.
DR AlphaFoldDB; Q8NGI0; -.
DR SMR; Q8NGI0; -.
DR STRING; 9606.ENSP00000322801; -.
DR GlyGen; Q8NGI0; 1 site.
DR PhosphoSitePlus; Q8NGI0; -.
DR BioMuta; OR52N2; -.
DR DMDM; 38372698; -.
DR PaxDb; Q8NGI0; -.
DR PeptideAtlas; Q8NGI0; -.
DR PRIDE; Q8NGI0; -.
DR ProteomicsDB; 73517; -.
DR Antibodypedia; 77885; 11 antibodies from 8 providers.
DR DNASU; 390077; -.
DR Ensembl; ENST00000317037.3; ENSP00000322801.2; ENSG00000180988.3.
DR GeneID; 390077; -.
DR KEGG; hsa:390077; -.
DR MANE-Select; ENST00000317037.3; ENSP00000322801.2; NM_001005174.3; NP_001005174.1.
DR UCSC; uc010qzp.3; human.
DR CTD; 390077; -.
DR DisGeNET; 390077; -.
DR GeneCards; OR52N2; -.
DR HGNC; HGNC:15228; OR52N2.
DR HPA; ENSG00000180988; Not detected.
DR neXtProt; NX_Q8NGI0; -.
DR PharmGKB; PA32426; -.
DR VEuPathDB; HostDB:ENSG00000180988; -.
DR eggNOG; ENOG502QV28; Eukaryota.
DR GeneTree; ENSGT01050000244847; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGI0; -.
DR OMA; HMCAIVI; -.
DR OrthoDB; 883265at2759; -.
DR PhylomeDB; Q8NGI0; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGI0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390077; 7 hits in 672 CRISPR screens.
DR GeneWiki; OR52N2; -.
DR GenomeRNAi; 390077; -.
DR Pharos; Q8NGI0; Tdark.
DR PRO; PR:Q8NGI0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGI0; protein.
DR Bgee; ENSG00000180988; Expressed in granulocyte and 25 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 52N2"
FT /id="PRO_0000150787"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 249
FT /note="S -> A (in dbSNP:rs8181529)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024150"
FT VARIANT 264
FT /note="H -> R (in dbSNP:rs8181512)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024151"
SQ SEQUENCE 321 AA; 35940 MW; A08A2658BD26477C CRC64;
MSGDNSSSLT PGFFILNGVP GLEATHIWIS LPFCFMYIIA VVGNCGLICL ISHEEALHRP
MYYFLALLSF TDVTLCTTMV PNMLCIFWFN LKEIDFNACL AQMFFVHMLT GMESGVLMLM
ALDRYVAICY PLRYATILTN PVIAKAGLAT FLRNVMLIIP FTLLTKRLPY CRGNFIPHTY
CDHMSVAKVS CGNFKVNAIY GLMVALLIGV FDICCISVSY TMILQAVMSL SSADARHKAF
STCTSHMCSI VITYVAAFFT FFTHRFVGHN IPNHIHIIVA NLYLLLPPTM NPIVYGVKTK
QIQEGVIKFL LGDKVSFTYD K
