O52N4_HUMAN
ID O52N4_HUMAN Reviewed; 321 AA.
AC Q8NGI2; B2RNP8; Q6IF77;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 52N4;
DE AltName: Full=Olfactory receptor OR11-64;
GN Name=OR52N4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-106; ARG-167; GLY-209
RP AND ILE-218.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS ILE-106;
RP ARG-167 AND ILE-218.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ILE-106; ARG-167 AND
RP ILE-218.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION, AND VARIANTS ILE-106; ARG-167; GLY-209 AND ILE-218.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [7]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon at position Arg-172 in the gene coding for
CC this protein is responsible for functional diversity thus producing a
CC pseudogene. The stop codon is more frequent in non-Africans than in
CC African-Americans.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52N4";
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DR EMBL; AB065813; BAC06032.1; -; Genomic_DNA.
DR EMBL; AC131574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68764.1; -; Genomic_DNA.
DR EMBL; BC137035; AAI37036.1; -; mRNA.
DR EMBL; BC137036; AAI37037.1; -; mRNA.
DR EMBL; BK004385; DAA04783.1; -; Genomic_DNA.
DR CCDS; CCDS44528.1; -.
DR RefSeq; NP_001005175.3; NM_001005175.3.
DR RefSeq; XP_016873200.1; XM_017017711.1.
DR RefSeq; XP_016873201.1; XM_017017712.1.
DR RefSeq; XP_016873202.1; XM_017017713.1.
DR AlphaFoldDB; Q8NGI2; -.
DR SMR; Q8NGI2; -.
DR BioGRID; 133384; 3.
DR STRING; 9606.ENSP00000323224; -.
DR GlyGen; Q8NGI2; 1 site.
DR iPTMnet; Q8NGI2; -.
DR PhosphoSitePlus; Q8NGI2; -.
DR BioMuta; OR52N4; -.
DR DMDM; 296439252; -.
DR PaxDb; Q8NGI2; -.
DR PRIDE; Q8NGI2; -.
DR Antibodypedia; 63620; 52 antibodies from 16 providers.
DR DNASU; 390072; -.
DR Ensembl; ENST00000641350.2; ENSP00000493338.1; ENSG00000181074.5.
DR GeneID; 390072; -.
DR KEGG; hsa:390072; -.
DR MANE-Select; ENST00000641350.2; ENSP00000493338.1; NM_001005175.5; NP_001005175.3.
DR UCSC; uc001mbu.3; human.
DR CTD; 390072; -.
DR GeneCards; OR52N4; -.
DR HGNC; HGNC:15230; OR52N4.
DR HPA; ENSG00000181074; Tissue enhanced (lymphoid).
DR neXtProt; NX_Q8NGI2; -.
DR OpenTargets; ENSG00000181074; -.
DR PharmGKB; PA32428; -.
DR VEuPathDB; HostDB:ENSG00000181074; -.
DR eggNOG; ENOG502QV28; Eukaryota.
DR GeneTree; ENSGT01050000244847; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGI2; -.
DR OMA; VAMAGNC; -.
DR PhylomeDB; Q8NGI2; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGI2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390072; 8 hits in 637 CRISPR screens.
DR ChiTaRS; OR52N4; human.
DR GeneWiki; OR52N4; -.
DR GenomeRNAi; 390072; -.
DR Pharos; Q8NGI2; Tdark.
DR PRO; PR:Q8NGI2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGI2; protein.
DR Bgee; ENSG00000181074; Expressed in granulocyte and 81 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 52N4"
FT /id="PRO_0000150788"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 106
FT /note="T -> I (in dbSNP:rs7936512)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3"
FT /id="VAR_034352"
FT VARIANT 167
FT /note="L -> R (in dbSNP:rs7394584)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3"
FT /id="VAR_053338"
FT VARIANT 209
FT /note="W -> G (in dbSNP:rs12363178)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1"
FT /id="VAR_053339"
FT VARIANT 218
FT /note="N -> I (in dbSNP:rs7396938)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3"
FT /id="VAR_034353"
SQ SEQUENCE 321 AA; 36080 MW; 756230B548736347 CRC64;
MLTLNKTDLI PASFILNGVP GLEDTQLWIS FPFCSMYVVA MVGNCGLLYL IHYEDALHKP
MYYFLAMLSF TDLVMCSSTI PKALCIFWFH LKDIGFDECL VQMFFTHTFT GMESGVLMLM
ALDRYVAICY PLRYSTILTN PVIAKVGTAT FLRGVLLIIP FTFLTKLLPY CRGNILPHTY
CDHMSVAKLS CGNVKVNAIY GLMVALLIWG FDILCITNSY TMILRAVVSL SSADARQKAF
NTCTAHICAI VFSYTPAFFS FFSHRFGEHI IPPSCHIIVA NIYLLLPPTM NPIVYGVKTK
QIRDCVIRIL SGSKDTKSYS M
