O52N5_HUMAN
ID O52N5_HUMAN Reviewed; 324 AA.
AC Q8NH56; B9EH12; Q6IFG2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 52N5;
DE AltName: Full=Olfactory receptor OR11-62;
GN Name=OR52N5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-133.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52N5";
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DR EMBL; AB065535; BAC05781.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68762.1; -; Genomic_DNA.
DR EMBL; BC136979; AAI36980.1; -; mRNA.
DR EMBL; BC136981; AAI36982.1; -; mRNA.
DR EMBL; BK004300; DAA04698.1; -; Genomic_DNA.
DR CCDS; CCDS31397.1; -.
DR RefSeq; NP_001001922.2; NM_001001922.2.
DR AlphaFoldDB; Q8NH56; -.
DR SMR; Q8NH56; -.
DR BioGRID; 133386; 5.
DR STRING; 9606.ENSP00000322866; -.
DR BioMuta; OR52N5; -.
DR DMDM; 212276449; -.
DR MassIVE; Q8NH56; -.
DR PaxDb; Q8NH56; -.
DR PeptideAtlas; Q8NH56; -.
DR PRIDE; Q8NH56; -.
DR Antibodypedia; 67180; 75 antibodies from 19 providers.
DR DNASU; 390075; -.
DR Ensembl; ENST00000317093.2; ENSP00000322866.2; ENSG00000181009.5.
DR Ensembl; ENST00000641181.1; ENSP00000493190.1; ENSG00000181009.5.
DR GeneID; 390075; -.
DR KEGG; hsa:390075; -.
DR MANE-Select; ENST00000641181.1; ENSP00000493190.1; NM_001385662.1; NP_001372591.1.
DR UCSC; uc010qzn.2; human.
DR CTD; 390075; -.
DR GeneCards; OR52N5; -.
DR HGNC; HGNC:15231; OR52N5.
DR HPA; ENSG00000181009; Not detected.
DR neXtProt; NX_Q8NH56; -.
DR OpenTargets; ENSG00000181009; -.
DR PharmGKB; PA32429; -.
DR VEuPathDB; HostDB:ENSG00000181009; -.
DR eggNOG; ENOG502QV28; Eukaryota.
DR GeneTree; ENSGT01050000244847; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH56; -.
DR OMA; CAMYAIS; -.
DR OrthoDB; 917902at2759; -.
DR PhylomeDB; Q8NH56; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NH56; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390075; 12 hits in 672 CRISPR screens.
DR GeneWiki; OR52N5; -.
DR GenomeRNAi; 390075; -.
DR Pharos; Q8NH56; Tdark.
DR PRO; PR:Q8NH56; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH56; protein.
DR Bgee; ENSG00000181009; Expressed in calcaneal tendon and 20 other tissues.
DR ExpressionAtlas; Q8NH56; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 52N5"
FT /id="PRO_0000150789"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 106..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 133
FT /note="V -> I (in dbSNP:rs12360738)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_047147"
SQ SEQUENCE 324 AA; 36212 MW; 71FAC1869435A50F CRC64;
MPLFNSLCWF PTIHVTPPSF ILNGIPGLER VHVWISLPLC TMYIIFLVGN LGLVYLIYYE
ESLHHPMYFF FGHALSLIDL LTCTTTLPNA LCIFWFSLKE INFNACLAQM FFVHGFTGVE
SGVLMLMALD RYVAICYPLR YATTLTNPII AKAELATFLR GVLLMIPFPF LVKRLPFCQS
NIISHTYCDH MSVVKLSCAS IKVNVIYGLM VALLIGVFDI CCISLSYTLI LKAAISLSSS
DARQKAFSTC TAHISAIIIT YVPAFFTFFA HRFGGHTIPP SLHIIVANLY LLLPPTLNPI
VYGVKTKQIR KSVIKFFQGD KGAG
