ID   O52P1_HUMAN             Reviewed;         321 AA.
AC   Q8NH57;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2003, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Olfactory receptor 52P1;
GN   Name=OR52P1 {ECO:0000312|HGNC:HGNC:15232}; Synonyms=OR52P1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- POLYMORPHISM: Segregating pseudogene, locus showing both intact and
CC       pseudogene forms in the population. This gene is a pseudogene on the
CC       reference genome but has been found to be protein coding in some
CC       individuals. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05780.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52P1P";
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DR   EMBL; AB065534; BAC05780.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q8NH57; -.
DR   SMR; Q8NH57; -.
DR   GlyGen; Q8NH57; 1 site.
DR   BioMuta; HGNC:15232; -.
DR   DMDM; 38372815; -.
DR   MassIVE; Q8NH57; -.
DR   PRIDE; Q8NH57; -.
DR   GeneCards; OR52P1P; -.
DR   HGNC; HGNC:15232; OR52P1.
DR   neXtProt; NX_Q8NH57; -.
DR   InParanoid; Q8NH57; -.
DR   PhylomeDB; Q8NH57; -.
DR   PathwayCommons; Q8NH57; -.
DR   Pharos; Q8NH57; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8NH57; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..321
FT                   /note="Olfactory receptor 52P1"
FT                   /id="PRO_0000150790"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..191
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   321 AA;  34890 MW;  47329FE6ADC8CF22 CRC64;
     MESPNHTDVD PSVFFLLGIP GLEQFHLWLS LPVCGLGTAT IVGNITILVV VATEPVLHKP
     VYLFLCMLST IDLAASVSTV PKLLAIFWCG AGHISASACL AQMFFIHAFC MMESTVLLAM
     AFDRYVAICH PLRYATILTD TIIAHIGVAA VVRGSLLMLP CPFLIGRLNF CQSHVILHTY
     CEHMAVVKLA CGDTRPNRVY GLTAALLVIG VDLFCIGLSY ALSAQAVLRL SSHEARSKAL
     GTCGSHVCVI LISYTPALFS FFTHRFGHHV PVHIHILLAN VYLLLPPALN PVVYGVKTKQ
     IRKRVVRVFQ SGQGMGIKAS E