O52R1_HUMAN
ID O52R1_HUMAN Reviewed; 315 AA.
AC Q8NGF1; Q6IFI0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 52R1;
DE AltName: Full=Olfactory receptor OR11-22;
GN Name=OR52R1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-129; TYR-201 AND
RP ALA-245.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION, AND VARIANTS THR-129; TYR-201 AND ALA-245.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04680.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52R1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065857; BAC06075.1; -; Genomic_DNA.
DR EMBL; AC103710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004282; DAA04680.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_001005177.3; NM_001005177.3.
DR AlphaFoldDB; Q8NGF1; -.
DR SMR; Q8NGF1; -.
DR STRING; 9606.ENSP00000348368; -.
DR GlyGen; Q8NGF1; 1 site.
DR BioMuta; OR52R1; -.
DR DMDM; 223590113; -.
DR MaxQB; Q8NGF1; -.
DR PaxDb; Q8NGF1; -.
DR PeptideAtlas; Q8NGF1; -.
DR PRIDE; Q8NGF1; -.
DR Antibodypedia; 78535; 27 antibodies from 10 providers.
DR DNASU; 119695; -.
DR Ensembl; ENST00000624978.1; ENSP00000485292.1; ENSG00000279270.2.
DR GeneID; 119695; -.
DR KEGG; hsa:119695; -.
DR MANE-Select; ENST00000624978.1; ENSP00000485292.1; NM_001005177.3; NP_001005177.3.
DR UCSC; uc021qcs.1; human.
DR CTD; 119695; -.
DR DisGeNET; 119695; -.
DR GeneCards; OR52R1; -.
DR HGNC; HGNC:15235; OR52R1.
DR HPA; ENSG00000279270; Not detected.
DR neXtProt; NX_Q8NGF1; -.
DR PharmGKB; PA32433; -.
DR VEuPathDB; HostDB:ENSG00000279270; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244847; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGF1; -.
DR OMA; RMPFCQH; -.
DR OrthoDB; 908535at2759; -.
DR PhylomeDB; Q8NGF1; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q8NGF1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 119695; 8 hits in 660 CRISPR screens.
DR GeneWiki; OR52R1; -.
DR GenomeRNAi; 119695; -.
DR Pharos; Q8NGF1; Tdark.
DR PRO; PR:Q8NGF1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGF1; protein.
DR Bgee; ENSG00000279270; Expressed in prostate gland.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 52R1"
FT /id="PRO_0000150791"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 88
FT /note="F -> L (in dbSNP:rs17327254)"
FT /id="VAR_059061"
FT VARIANT 129
FT /note="I -> T (in dbSNP:rs7941731)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1"
FT /id="VAR_059062"
FT VARIANT 201
FT /note="N -> Y (in dbSNP:rs6578533)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1"
FT /id="VAR_059063"
FT VARIANT 245
FT /note="S -> A (in dbSNP:rs2053116)"
FT /evidence="ECO:0000269|PubMed:14983052, ECO:0000269|Ref.1"
FT /id="VAR_059064"
SQ SEQUENCE 315 AA; 34943 MW; F60B7F7362F43137 CRC64;
MVLASGNSSS HPVSFILLGI PGLESFQLWI AFPFCATYAV AVVGNITLLH VIRIDHTLHE
PMYLFLAMLA ITDLVLSSST QPKMLAIFWF HAHEIQYHAC LIQVFFIHAF SSVESGVLMA
MALDCYVAIC FPLRHSSILT PSVVIKLGTI VMLRGLLWVS PFCFMVSRMP FCQHQAIPQS
YCEHMAVLKL VCADTSISRG NGLFVAFSVA GFDMIVIGMS YVMILRAVLQ LPSGEARLKA
FSTRSSHICV ILALYIPALF SFLTYRFGHD VPRVVHILFA NLYLLIPPML NPIIYGVRTK
QIGDRVIQGC CGNIP
