O52W1_HUMAN
ID O52W1_HUMAN Reviewed; 320 AA.
AC Q6IF63; Q8NH78;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 52W1;
DE AltName: Full=Olfactory receptor OR11-71;
GN Name=OR52W1; Synonyms=OR52W1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-266.
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52W1";
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DR EMBL; AB065511; BAC05759.1; -; Genomic_DNA.
DR EMBL; AC036216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137225; AAI37226.1; -; mRNA.
DR EMBL; BK004399; DAA04797.1; -; Genomic_DNA.
DR CCDS; CCDS31407.1; -.
DR RefSeq; NP_001005178.1; NM_001005178.1.
DR AlphaFoldDB; Q6IF63; -.
DR SMR; Q6IF63; -.
DR BioGRID; 125694; 2.
DR IntAct; Q6IF63; 2.
DR STRING; 9606.ENSP00000309673; -.
DR GlyGen; Q6IF63; 1 site.
DR iPTMnet; Q6IF63; -.
DR PhosphoSitePlus; Q6IF63; -.
DR BioMuta; OR52W1; -.
DR DMDM; 205525921; -.
DR PaxDb; Q6IF63; -.
DR PeptideAtlas; Q6IF63; -.
DR PRIDE; Q6IF63; -.
DR Antibodypedia; 57976; 60 antibodies from 16 providers.
DR DNASU; 120787; -.
DR Ensembl; ENST00000311352.3; ENSP00000309673.2; ENSG00000175485.3.
DR GeneID; 120787; -.
DR KEGG; hsa:120787; -.
DR MANE-Select; ENST00000311352.3; ENSP00000309673.2; NM_001005178.1; NP_001005178.1.
DR UCSC; uc010qzz.3; human.
DR CTD; 120787; -.
DR GeneCards; OR52W1; -.
DR HGNC; HGNC:15239; OR52W1.
DR HPA; ENSG00000175485; Not detected.
DR neXtProt; NX_Q6IF63; -.
DR OpenTargets; ENSG00000175485; -.
DR PharmGKB; PA32453; -.
DR VEuPathDB; HostDB:ENSG00000175485; -.
DR eggNOG; ENOG502T9KV; Eukaryota.
DR GeneTree; ENSGT01050000244932; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q6IF63; -.
DR OMA; FEHFQAK; -.
DR OrthoDB; 900491at2759; -.
DR PhylomeDB; Q6IF63; -.
DR TreeFam; TF343679; -.
DR PathwayCommons; Q6IF63; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q6IF63; -.
DR BioGRID-ORCS; 120787; 9 hits in 670 CRISPR screens.
DR GeneWiki; OR52W1; -.
DR GenomeRNAi; 120787; -.
DR Pharos; Q6IF63; Tdark.
DR PRO; PR:Q6IF63; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6IF63; protein.
DR Bgee; ENSG00000175485; Expressed in prefrontal cortex and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 52W1"
FT /id="PRO_0000150792"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 239
FT /note="H -> R (in dbSNP:rs10839531)"
FT /id="VAR_044514"
FT VARIANT 254
FT /note="L -> Q (in dbSNP:rs11040799)"
FT /id="VAR_044515"
FT VARIANT 266
FT /note="T -> A (in dbSNP:rs325609)"
FT /evidence="ECO:0000269|PubMed:16554811"
FT /id="VAR_044516"
SQ SEQUENCE 320 AA; 34414 MW; B3E2EF68C32733B2 CRC64;
MAETLQLNST FLHPNFFILT GFPGLGSAQT WLTLVFGPIY LLALLGNGAL PAVVWIDSTL
HQPMFLLLAI LAATDLGLAT SIAPGLLAVL WLGPRSVPYA VCLVQMFFVH ALTAMESGVL
LAMACDRAAA IGRPLHYPVL VTKACVGYAA LALALKAVAI VVPFPLLVAK FEHFQAKTIG
HTYCAHMAVV ELVVGNTQAT NLYGLALSLA ISGMDILGIT GSYGLIAHAV LQLPTREAHA
KAFGTCSSHI CVILAFYIPG LFSYLTHRFG HHTVPKPVHI LLSNIYLLLP PALNPLIYGA
RTKQIRDRLL ETFTFRKSPL
