O52Z1_HUMAN
ID O52Z1_HUMAN Reviewed; 298 AA.
AC P0C646; A0A087X1Z4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Olfactory receptor 52Z1P;
GN Name=OR52Z1P {ECO:0000312|HGNC:HGNC:19596}; Synonyms=OR52Z1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP POLYMORPHISM.
RX PubMed=17973576; DOI=10.1371/journal.pbio.0050284;
RA Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W.,
RA Lancet D.;
RT "Genetic elucidation of human hyperosmia to isovaleric acid.";
RL PLoS Biol. 5:2462-2468(2007).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- POLYMORPHISM: Segregating pseudogene, locus showing both intact and
CC pseudogene forms in the population. A single nucleotide insertion at
CC position Gly-8 in the gene coding for this protein is responsible for
CC functional diversity thus producing a pseudogene.
CC {ECO:0000305|PubMed:17973576}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52Z1P";
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DR EMBL; AC129505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001335186.1; NM_001348257.1.
DR AlphaFoldDB; P0C646; -.
DR SMR; P0C646; -.
DR BioMuta; OR52Z1; -.
DR DMDM; 166215761; -.
DR PRIDE; P0C646; -.
DR ProteomicsDB; 52322; -.
DR DNASU; 283110; -.
DR GeneID; 283110; -.
DR CTD; 283110; -.
DR DisGeNET; 283110; -.
DR GeneCards; OR52Z1; -.
DR HGNC; HGNC:19596; OR52Z1P.
DR neXtProt; NX_P0C646; -.
DR InParanoid; P0C646; -.
DR OrthoDB; 915962at2759; -.
DR PhylomeDB; P0C646; -.
DR PathwayCommons; P0C646; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; P0C646; Tdark.
DR PRO; PR:P0C646; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0C646; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..298
FT /note="Olfactory receptor 52Z1P"
FT /id="PRO_0000315944"
FT TOPO_DOM 1..14
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..223
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 83..164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 298 AA; 33382 MW; 6DA6307EE1554B3B CRC64;
MGIPGLEGLH TWISIPFSFM YIVAVAGNIF LIFLIMTERS LHEPMYLFLS MLASADFLLA
TAAAPKVLAI LWFHSMDISF GSCVSQMFFI HFIFVAESAI LLAMAFDRYV AICYPLRYTI
LTSSAVRKIG IAAVVRSFFI CCPFIFLVYR LTYCGRNIIP HSYCEHIARL ACGNINVNII
YGLTVALLST GLDIVLIIIS YTMILHSVFQ ISSWAARFKA LSTCGSHICV IFMFYTPAFF
SFLAHRFGGK TIPHHIHILV GSLYVLVPPM LNPIIYGVKT KQIKDRVILL FSPISVCC
