O56A1_HUMAN
ID O56A1_HUMAN Reviewed; 318 AA.
AC Q8NGH5; B2RNI2; Q6IFL0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 56A1;
DE AltName: Full=Olfactory receptor OR11-75;
GN Name=OR56A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR56A1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065821; BAC06040.1; -; Genomic_DNA.
DR EMBL; AC111177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136904; AAI36905.1; -; mRNA.
DR EMBL; BC136911; AAI36912.1; -; mRNA.
DR EMBL; BK004252; DAA04650.1; -; Genomic_DNA.
DR RefSeq; NP_001001917.2; NM_001001917.2.
DR AlphaFoldDB; Q8NGH5; -.
DR SMR; Q8NGH5; -.
DR STRING; 9606.ENSP00000321246; -.
DR GlyGen; Q8NGH5; 3 sites.
DR iPTMnet; Q8NGH5; -.
DR PhosphoSitePlus; Q8NGH5; -.
DR BioMuta; OR56A1; -.
DR DMDM; 229462958; -.
DR MassIVE; Q8NGH5; -.
DR PaxDb; Q8NGH5; -.
DR PeptideAtlas; Q8NGH5; -.
DR PRIDE; Q8NGH5; -.
DR ProteomicsDB; 73512; -.
DR DNASU; 120796; -.
DR GeneID; 120796; -.
DR KEGG; hsa:120796; -.
DR UCSC; uc010qzw.2; human.
DR CTD; 120796; -.
DR GeneCards; OR56A1; -.
DR HGNC; HGNC:14781; OR56A1.
DR neXtProt; NX_Q8NGH5; -.
DR PharmGKB; PA32443; -.
DR eggNOG; ENOG502SJUD; Eukaryota.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGH5; -.
DR OrthoDB; 1111013at2759; -.
DR PhylomeDB; Q8NGH5; -.
DR TreeFam; TF344049; -.
DR PathwayCommons; Q8NGH5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 120796; 8 hits in 638 CRISPR screens.
DR GeneWiki; OR56A1; -.
DR GenomeRNAi; 120796; -.
DR Pharos; Q8NGH5; Tdark.
DR PRO; PR:Q8NGH5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGH5; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 56A1"
FT /id="PRO_0000150793"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 22
FT /note="I -> T (in Ref. 1; BAC06040)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35823 MW; D0174EFA5005C677 CRC64;
MIQPMASPSN SSTVPVSEFL LICFPNFQSW QHWLSLPLSL LFLLAMGANT TLLITIQLEA
SLHQPLYYLL SLLSLLDIVL CLTVIPKVLA IFWYDLRSIS FPACFLQMFI MNSFLPMESC
TFMVMAYDRY VAICHPLRYP SIITNQFVAK ASVFIVVRNA LLTAPIPILT SLLHYCGENV
IENCICANLS VSRLSCDNFT LNRIYQFVAG WTLLGSDLFL IFLSYTFILR AVLRFKAEGA
AVKALSTCGS HFILILFFST ILLVVVLTNV ARKKVPMDIL ILLNVLHHLI PPALNPIVYG
VRTKEIKQGI QKLLQRGR
