O56A3_HUMAN
ID O56A3_HUMAN Reviewed; 315 AA.
AC Q8NH54; A6NN77; Q6IFF7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 56A3;
DE AltName: Full=Olfactory receptor 56A6;
GN Name=OR56A3; Synonyms=OR56A3P, OR56A6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05783.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR56A3";
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DR EMBL; AB065537; BAC05783.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC025016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004305; DAA04703.1; -; Genomic_DNA.
DR CCDS; CCDS41614.1; -.
DR RefSeq; NP_001003443.2; NM_001003443.2.
DR AlphaFoldDB; Q8NH54; -.
DR SMR; Q8NH54; -.
DR BioGRID; 133392; 1.
DR IntAct; Q8NH54; 1.
DR STRING; 9606.ENSP00000331572; -.
DR GlyGen; Q8NH54; 2 sites.
DR iPTMnet; Q8NH54; -.
DR PhosphoSitePlus; Q8NH54; -.
DR BioMuta; OR56A3; -.
DR DMDM; 38372812; -.
DR MassIVE; Q8NH54; -.
DR PaxDb; Q8NH54; -.
DR PeptideAtlas; Q8NH54; -.
DR PRIDE; Q8NH54; -.
DR ProteomicsDB; 73662; -.
DR Antibodypedia; 57955; 45 antibodies from 14 providers.
DR DNASU; 390083; -.
DR Ensembl; ENST00000641160.1; ENSP00000493059.1; ENSG00000184478.8.
DR Ensembl; ENST00000641905.1; ENSP00000493319.1; ENSG00000184478.8.
DR GeneID; 390083; -.
DR KEGG; hsa:390083; -.
DR MANE-Select; ENST00000641160.1; ENSP00000493059.1; NM_001003443.3; NP_001003443.2.
DR UCSC; uc010qzt.3; human.
DR CTD; 390083; -.
DR GeneCards; OR56A3; -.
DR HGNC; HGNC:14786; OR56A3.
DR HPA; ENSG00000184478; Not detected.
DR neXtProt; NX_Q8NH54; -.
DR PharmGKB; PA32445; -.
DR VEuPathDB; HostDB:ENSG00000184478; -.
DR eggNOG; ENOG502SJUD; Eukaryota.
DR GeneTree; ENSGT00940000155550; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH54; -.
DR OMA; RLQYCGR; -.
DR OrthoDB; 1096499at2759; -.
DR PhylomeDB; Q8NH54; -.
DR TreeFam; TF344049; -.
DR PathwayCommons; Q8NH54; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH54; -.
DR BioGRID-ORCS; 390083; 6 hits in 666 CRISPR screens.
DR GeneWiki; OR56A3; -.
DR GenomeRNAi; 390083; -.
DR Pharos; Q8NH54; Tdark.
DR PRO; PR:Q8NH54; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH54; protein.
DR Bgee; ENSG00000184478; Expressed in cortical plate and 14 other tissues.
DR ExpressionAtlas; Q8NH54; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 56A3"
FT /id="PRO_0000150794"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..193
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 51
FT /note="M -> T (in dbSNP:rs1840178)"
FT /id="VAR_024152"
SQ SEQUENCE 315 AA; 35611 MW; 66DEE7264A41BD0F CRC64;
MTTHRNDTLS TEASDFLLNC FVRSPSWQHW LSLPLSLLFL LAVGANTTLL MTIWLEASLH
QPLYYLLSLL SLLDIVLCLT VIPKVLTIFW FDLRPISFPA CFLQMYIMNC FLAMESCTFM
VMAYDRYVAI CHPLRYPSII TDHFVVKAAM FILTRNVLMT LPIPILSAQL RYCGRNVIEN
CICANMSVSR LSCDDVTINH LYQFAGGWTL LGSDLILIFL SYTFILRAVL RLKAEGAVAK
ALSTCGSHFM LILFFSTILL VFVLTHVAKK KVSPDVPVLL NVLHHVIPAA LNPIIYGVRT
QEIKQGMQRL LKKGC
