O56A4_HUMAN
ID O56A4_HUMAN Reviewed; 313 AA.
AC Q8NGH8; B9EH17;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 56A4;
DE AltName: Full=Olfactory receptor OR11-49;
GN Name=OR56A4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI36987.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR56A4";
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DR EMBL; AB065818; BAC06037.1; -; Genomic_DNA.
DR EMBL; AC111177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136986; AAI36987.1; ALT_INIT; mRNA.
DR CCDS; CCDS31404.1; -.
DR RefSeq; NP_001005179.2; NM_001005179.2.
DR AlphaFoldDB; Q8NGH8; -.
DR SMR; Q8NGH8; -.
DR BioGRID; 125695; 1.
DR STRING; 9606.ENSP00000328215; -.
DR GlyGen; Q8NGH8; 2 sites.
DR BioMuta; OR56A4; -.
DR DMDM; 259016292; -.
DR MassIVE; Q8NGH8; -.
DR PaxDb; Q8NGH8; -.
DR PeptideAtlas; Q8NGH8; -.
DR PRIDE; Q8NGH8; -.
DR Antibodypedia; 23754; 13 antibodies from 9 providers.
DR DNASU; 120793; -.
DR Ensembl; ENST00000641156.1; ENSP00000492932.1; ENSG00000183389.5.
DR Ensembl; ENST00000641279.1; ENSP00000492934.1; ENSG00000183389.5.
DR Ensembl; ENST00000641835.1; ENSP00000493371.1; ENSG00000183389.5.
DR GeneID; 120793; -.
DR KEGG; hsa:120793; -.
DR MANE-Select; ENST00000641156.1; ENSP00000492932.1; NM_001005179.4; NP_001005179.3.
DR UCSC; uc010qzv.3; human.
DR CTD; 120793; -.
DR GeneCards; OR56A4; -.
DR HGNC; HGNC:14791; OR56A4.
DR HPA; ENSG00000183389; Not detected.
DR neXtProt; NX_Q8NGH8; -.
DR OpenTargets; ENSG00000183389; -.
DR PharmGKB; PA32446; -.
DR VEuPathDB; HostDB:ENSG00000183389; -.
DR eggNOG; ENOG502SJUD; Eukaryota.
DR GeneTree; ENSGT00940000161235; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGH8; -.
DR OrthoDB; 1111013at2759; -.
DR PhylomeDB; Q8NGH8; -.
DR TreeFam; TF344049; -.
DR PathwayCommons; Q8NGH8; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGH8; -.
DR BioGRID-ORCS; 120793; 6 hits in 669 CRISPR screens.
DR GeneWiki; OR56A4; -.
DR GenomeRNAi; 120793; -.
DR Pharos; Q8NGH8; Tdark.
DR PRO; PR:Q8NGH8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGH8; protein.
DR Bgee; ENSG00000183389; Expressed in anatomical system and 5 other tissues.
DR ExpressionAtlas; Q8NGH8; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 56A4"
FT /id="PRO_0000150795"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 5
FT /note="S -> N (in Ref. 1; BAC06037)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35116 MW; 5DC90F4F796373FE CRC64;
MASPSNDSTA PVSEFLLICF PNFQSWQHWL SLPLSLLFLL AMGANTTLLI TIQLEASLHQ
PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC FLQMFIMNSF LTMESCTFMV
MAYDRYVAIC HPLRYPSIIT DQFVARAVVF VIARNAFVSL PVPMLSARLR YCAGNIIKNC
ICSNLSVSKL SCDDITFNQL YQFVAGWTLL GSDLILIVIS YSFILKVVLR IKAEGAVAKA
LSTCGSHFIL ILFFSTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK
EIKQGIQNLL KRL
