O56A5_HUMAN
ID O56A5_HUMAN Reviewed; 313 AA.
AC P0C7T3;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Olfactory receptor 56A5;
GN Name=OR56A5; Synonyms=OR56A5P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR56A5";
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DR EMBL; AC025016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS73248.1; -.
DR RefSeq; NP_001139505.1; NM_001146033.1.
DR AlphaFoldDB; P0C7T3; -.
DR SMR; P0C7T3; -.
DR STRING; 9606.ENSP00000481594; -.
DR GlyGen; P0C7T3; 4 sites.
DR BioMuta; OR56A5; -.
DR DMDM; 206557833; -.
DR PeptideAtlas; P0C7T3; -.
DR PRIDE; P0C7T3; -.
DR Antibodypedia; 79119; 1 antibodies from 1 providers.
DR DNASU; 390084; -.
DR Ensembl; ENST00000532411.2; ENSP00000481594.1; ENSG00000188691.5.
DR GeneID; 390084; -.
DR KEGG; hsa:390084; -.
DR MANE-Select; ENST00000532411.2; ENSP00000481594.1; NM_001146033.1; NP_001139505.1.
DR UCSC; uc010qzu.2; human.
DR CTD; 390084; -.
DR GeneCards; OR56A5; -.
DR HGNC; HGNC:14792; OR56A5.
DR HPA; ENSG00000188691; Not detected.
DR neXtProt; NX_P0C7T3; -.
DR PharmGKB; PA32447; -.
DR VEuPathDB; HostDB:ENSG00000188691; -.
DR eggNOG; ENOG502SJUD; Eukaryota.
DR GeneTree; ENSGT00940000162834; -.
DR InParanoid; P0C7T3; -.
DR OMA; RIPHDVP; -.
DR OrthoDB; 1111013at2759; -.
DR PhylomeDB; P0C7T3; -.
DR PathwayCommons; P0C7T3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390084; 9 hits in 178 CRISPR screens.
DR GenomeRNAi; 390084; -.
DR Pharos; P0C7T3; Tdark.
DR PRO; PR:P0C7T3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P0C7T3; protein.
DR Bgee; ENSG00000188691; Expressed in blood and 2 other tissues.
DR ExpressionAtlas; P0C7T3; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 56A5"
FT /id="PRO_0000343673"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 313 AA; 35317 MW; 8E4CE42666CEC833 CRC64;
MTLPSNNSTS PVFEFFLICF PSFQSWQHWL SLPLSLLFLL AMGANATLLI TIYLEASLHQ
PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC FLQVFIMNSF LTMESCTFMI
MAYDRYVAIC KPLQYSSIIT DQFVARAAIF VVARNGLLTM PIPILSSRLR YCAGHIIKNC
ICTNVSVSKL SCDDITLNQS YQFVIGWTLL GSDLILIVLS YFFILKTVLR IKGEGDMAKA
LGTCGSHFIL ILFFTTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK
EIKQGIQNLL RRL
