O56B4_HUMAN
ID O56B4_HUMAN Reviewed; 319 AA.
AC Q8NH76; Q6IFD7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 56B4;
DE AltName: Full=Olfactory receptor OR11-67;
GN Name=OR56B4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR56B4";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065513; BAC05761.1; -; Genomic_DNA.
DR EMBL; BC136879; AAI36880.1; -; mRNA.
DR EMBL; BC136880; AAI36881.1; -; mRNA.
DR EMBL; BK004325; DAA04723.1; -; Genomic_DNA.
DR CCDS; CCDS31406.1; -.
DR RefSeq; NP_001005181.1; NM_001005181.2.
DR AlphaFoldDB; Q8NH76; -.
DR SMR; Q8NH76; -.
DR BioGRID; 128197; 1.
DR STRING; 9606.ENSP00000321196; -.
DR PhosphoSitePlus; Q8NH76; -.
DR BioMuta; OR56B4; -.
DR DMDM; 38372824; -.
DR PaxDb; Q8NH76; -.
DR PeptideAtlas; Q8NH76; -.
DR PRIDE; Q8NH76; -.
DR Antibodypedia; 57970; 49 antibodies from 16 providers.
DR DNASU; 196335; -.
DR Ensembl; ENST00000316529.3; ENSP00000321196.2; ENSG00000180919.3.
DR GeneID; 196335; -.
DR KEGG; hsa:196335; -.
DR MANE-Select; ENST00000316529.3; ENSP00000321196.2; NM_001005181.2; NP_001005181.1.
DR UCSC; uc010qzx.3; human.
DR CTD; 196335; -.
DR GeneCards; OR56B4; -.
DR HGNC; HGNC:15248; OR56B4.
DR HPA; ENSG00000180919; Not detected.
DR neXtProt; NX_Q8NH76; -.
DR PharmGKB; PA32453; -.
DR VEuPathDB; HostDB:ENSG00000180919; -.
DR eggNOG; ENOG502SJUD; Eukaryota.
DR GeneTree; ENSGT01050000244929; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NH76; -.
DR OMA; KAFVFKA; -.
DR OrthoDB; 1012273at2759; -.
DR PhylomeDB; Q8NH76; -.
DR TreeFam; TF344049; -.
DR PathwayCommons; Q8NH76; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 196335; 10 hits in 669 CRISPR screens.
DR GeneWiki; OR56B4; -.
DR GenomeRNAi; 196335; -.
DR Pharos; Q8NH76; Tdark.
DR PRO; PR:Q8NH76; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH76; protein.
DR Bgee; ENSG00000180919; Expressed in smooth muscle tissue and 11 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 56B4"
FT /id="PRO_0000150798"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 103..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 277
FT /note="P -> S (in dbSNP:rs1462983)"
FT /id="VAR_024153"
SQ SEQUENCE 319 AA; 35454 MW; 2D369DB81013EDEC CRC64;
MDTSTSVTYD SSLQISQFIL MGLPGIHEWQ HWLSLPLTLL YLLALGANLL IIITIQHETV
LHEPMYHLLG ILAVVDIGLA TTIMPKILAI FWFDAKAISL PMCFAQIYAI HCFFCIESGI
FLCMAVDRYI AICRPLQYPS IVTKAFVFKA TGFIMLRNGL LTIPVPILAA QRHYCSRNEI
EHCLCSNLGV ISLACDDITV NKFYQLMLAW VLVGSDMALV FSSYAVILHS VLRLNSAEAM
SKALSTCSSH LILILFHTGI IVLSVTHLAE KKIPLIPVFL NVLHNVIPPA LNPLACALRM
HKLRLGFQRL LGLGQDVSK
