O5AC2_HUMAN
ID O5AC2_HUMAN Reviewed; 309 AA.
AC Q9NZP5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 5AC2;
DE AltName: Full=HSA1;
GN Name=OR5AC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-287, AND VARIANT ILE-200.
RX PubMed=10706615; DOI=10.1073/pnas.040580197;
RA Rouquier S., Blancher A., Giorgi D.;
RT "The olfactory receptor gene repertoire in primates and mouse: evidence for
RT reduction of the functional fraction in primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AC2";
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DR EMBL; AC133439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF179759; AAF40348.1; -; Genomic_DNA.
DR CCDS; CCDS33796.1; -.
DR RefSeq; NP_473447.1; NM_054106.1.
DR AlphaFoldDB; Q9NZP5; -.
DR SMR; Q9NZP5; -.
DR BioGRID; 123356; 1.
DR STRING; 9606.ENSP00000351466; -.
DR GlyGen; Q9NZP5; 1 site.
DR iPTMnet; Q9NZP5; -.
DR PhosphoSitePlus; Q9NZP5; -.
DR BioMuta; OR5AC2; -.
DR DMDM; 85541038; -.
DR MassIVE; Q9NZP5; -.
DR PaxDb; Q9NZP5; -.
DR PeptideAtlas; Q9NZP5; -.
DR PRIDE; Q9NZP5; -.
DR Antibodypedia; 66601; 56 antibodies from 14 providers.
DR DNASU; 81050; -.
DR Ensembl; ENST00000358642.2; ENSP00000351466.2; ENSG00000196578.4.
DR GeneID; 81050; -.
DR KEGG; hsa:81050; -.
DR MANE-Select; ENST00000358642.2; ENSP00000351466.2; NM_054106.1; NP_473447.1.
DR UCSC; uc011bgs.2; human.
DR CTD; 81050; -.
DR GeneCards; OR5AC2; -.
DR HGNC; HGNC:15431; OR5AC2.
DR HPA; ENSG00000196578; Not detected.
DR neXtProt; NX_Q9NZP5; -.
DR OpenTargets; ENSG00000196578; -.
DR PharmGKB; PA32457; -.
DR VEuPathDB; HostDB:ENSG00000196578; -.
DR eggNOG; ENOG502RU05; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9NZP5; -.
DR OMA; CRFNIIH; -.
DR OrthoDB; 1037235at2759; -.
DR PhylomeDB; Q9NZP5; -.
DR TreeFam; TF352737; -.
DR PathwayCommons; Q9NZP5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9NZP5; -.
DR BioGRID-ORCS; 81050; 4 hits in 633 CRISPR screens.
DR GeneWiki; OR5AC2; -.
DR GenomeRNAi; 81050; -.
DR Pharos; Q9NZP5; Tdark.
DR PRO; PR:Q9NZP5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9NZP5; protein.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 5AC2"
FT /id="PRO_0000150574"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 200
FT /note="M -> I (in dbSNP:rs4518168)"
FT /evidence="ECO:0000269|PubMed:10706615"
FT /id="VAR_034214"
SQ SEQUENCE 309 AA; 35304 MW; BB9FD5CD01F0C5A9 CRC64;
MDISEGNKTL VTEFVLTGLT DRPWLHVLFF VVFLVVYLIT MVGNLGLIVL IWNDPHLHMP
MYLFLGGLAF SDACTSTSIT PRMLVNFLDK TAMISLAECI TQFYFFASSA TTECFLLVMM
AYDRYVAICN PLLYPVMMSN KLSAQLLSIS YVIGFLHPLV HVSLLLRLTF CRFNIIHYFY
CEILQLFKIS CNGPSINALM IFIFGAFIQI PTLMTIIISY TRVLFDILKK KSEKGRSKAF
STCGAHLLSV SLYYGTLIFM YVRPASGLAE DQDKVYSLFY TIIIPLLNPF IYSLRNKKVM
HALRRVIRK
