ID   O5AK2_HUMAN             Reviewed;         309 AA.
AC   Q8NH90; B2RNZ9;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Olfactory receptor 5AK2;
GN   Name=OR5AK2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-92.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AK2";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065496; BAC05747.1; -; Genomic_DNA.
DR   EMBL; BC137198; AAI37199.1; -; mRNA.
DR   CCDS; CCDS31538.1; -.
DR   RefSeq; NP_001005323.1; NM_001005323.1.
DR   AlphaFoldDB; Q8NH90; -.
DR   SMR; Q8NH90; -.
DR   STRING; 9606.ENSP00000322784; -.
DR   GlyGen; Q8NH90; 3 sites.
DR   BioMuta; OR5AK2; -.
DR   DMDM; 38372829; -.
DR   MassIVE; Q8NH90; -.
DR   PaxDb; Q8NH90; -.
DR   PeptideAtlas; Q8NH90; -.
DR   PRIDE; Q8NH90; -.
DR   ProteomicsDB; 73687; -.
DR   Antibodypedia; 66686; 61 antibodies from 16 providers.
DR   DNASU; 390181; -.
DR   Ensembl; ENST00000326855.3; ENSP00000322784.2; ENSG00000181273.3.
DR   GeneID; 390181; -.
DR   KEGG; hsa:390181; -.
DR   MANE-Select; ENST00000326855.3; ENSP00000322784.2; NM_001005323.1; NP_001005323.1.
DR   UCSC; uc010rjp.3; human.
DR   CTD; 390181; -.
DR   GeneCards; OR5AK2; -.
DR   HGNC; HGNC:15251; OR5AK2.
DR   HPA; ENSG00000181273; Tissue enriched (lymphoid).
DR   neXtProt; NX_Q8NH90; -.
DR   PharmGKB; PA32460; -.
DR   VEuPathDB; HostDB:ENSG00000181273; -.
DR   eggNOG; ENOG502RF3K; Eukaryota.
DR   GeneTree; ENSGT01040000240414; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NH90; -.
DR   OMA; MATILKM; -.
DR   OrthoDB; 911485at2759; -.
DR   PhylomeDB; Q8NH90; -.
DR   TreeFam; TF352756; -.
DR   PathwayCommons; Q8NH90; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390181; 8 hits in 619 CRISPR screens.
DR   GeneWiki; OR5AK2; -.
DR   GenomeRNAi; 390181; -.
DR   Pharos; Q8NH90; Tdark.
DR   PRO; PR:Q8NH90; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH90; protein.
DR   Bgee; ENSG00000181273; Expressed in spleen and 8 other tissues.
DR   ExpressionAtlas; Q8NH90; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Olfactory receptor 5AK2"
FT                   /id="PRO_0000150575"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        155
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        265
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         4
FT                   /note="G -> V (in dbSNP:rs10896563)"
FT                   /id="VAR_034215"
FT   VARIANT         43
FT                   /note="S -> T (in dbSNP:rs12420424)"
FT                   /id="VAR_060007"
FT   VARIANT         92
FT                   /note="M -> I (in dbSNP:rs2853083)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_034216"
SQ   SEQUENCE   309 AA;  34627 MW;  6022418115A44AC4 CRC64;
     MTLGNSTEVT EFYLLGFGAQ HEFWCILFIV FLLIYVTSIM GNSGIILLIN TDSRFQTLTY
     FFLQHLAFVD ICYTSAITPK MLQSFTEEKN LMLFQGCVIQ FLVYATFATS DCYLLAMMAV
     DPYVAICKPL HYTVIMSRTV CIRLVAGSYI MGSINASVQT GFTCSLSFCK SNSINHFFCD
     VPPILALSCS NVDINIMLLV VFVGSNLIFT GLVVIFSYIY IMATILKMSS SAGRKKSFST
     CASHLTAVTI FYGTLSYMYL QSHSNNSQEN MKVAFIFYGT VIPMLNPLIY SLRNKEVKEA
     LKVIGKKLF