O5AL1_HUMAN
ID O5AL1_HUMAN Reviewed; 329 AA.
AC P0C617;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2020, sequence version 2.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Olfactory receptor 5AL1;
DE AltName: Full=Olfactory receptor OR11-184;
GN Name=OR5AL1; Synonyms=OR5AL1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-155.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [2]
RP FUNCTION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [4]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305|PubMed:14983052}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A double nucleotide deletion, introducing a frameshift at
CC position 157 of the protein, results in an early stop codon producing a
CC pseudogene in a minority of the population.
CC {ECO:0000269|PubMed:12730696}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AL1P";
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DR EMBL; AF399353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001335159.1; NM_001348230.1.
DR AlphaFoldDB; P0C617; -.
DR SMR; P0C617; -.
DR GlyGen; P0C617; 1 site.
DR iPTMnet; P0C617; -.
DR PhosphoSitePlus; P0C617; -.
DR BioMuta; HGNC:14844; -.
DR DMDM; 166215763; -.
DR MassIVE; P0C617; -.
DR MaxQB; P0C617; -.
DR PRIDE; P0C617; -.
DR DNASU; 79482; -.
DR GeneID; 79482; -.
DR KEGG; hsa:79482; -.
DR CTD; 79482; -.
DR GeneCards; OR5AL1; -.
DR HGNC; HGNC:14844; OR5AL1.
DR neXtProt; NX_P0C617; -.
DR InParanoid; P0C617; -.
DR PhylomeDB; P0C617; -.
DR PathwayCommons; P0C617; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; P0C617; Tdark.
DR PRO; PR:P0C617; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0C617; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..329
FT /note="Olfactory receptor 5AL1"
FT /id="PRO_0000314462"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 113..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 329 AA; 36929 MW; E5D497781B929EB6 CRC64;
MCALKGFLEE NFYTYSVAKG NHSTVYEFIL LGLTDNAELQ VTLFGIFLVV YLASFMGNFG
LIMLIQISPQ LHTPMYFFLS HLAFVDFSFT SSVAPNTLVN FLCEVKSITF YACAIQVCCF
ITFVVCELYL LSIMAYDRYV AICNPLLYVI LIPRKLCIKL IASTYVYGFT VGLVQTVATS
YLSFCDSNVI NHFYHDDVPL VALACSDTHV KELMLLIIAG FNTLCSLVIV LISYGFIFFA
ILRIHSAEGR QKAFSTSASH LTSITIFYGT IIFMYPQPKS SHSLNMDKVA SVFNVVVIPT
LNPLIYSLRN QEVKNALKRI IEKLCLAVK
