O5AN1_HUMAN
ID O5AN1_HUMAN Reviewed; 311 AA.
AC Q8NGI8; B9EIS2; Q6IEV4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 5AN1;
DE AltName: Full=Olfactory receptor OR11-244;
GN Name=OR5AN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-289.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24361078; DOI=10.1016/j.neuron.2013.10.021;
RA Shirasu M., Yoshikawa K., Takai Y., Nakashima A., Takeuchi H., Sakano H.,
RA Touhara K.;
RT "Olfactory receptor and neural pathway responsible for highly selective
RT sensing of musk odors.";
RL Neuron 81:165-178(2014).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=25901328; DOI=10.1073/pnas.1503054112;
RA Block E., Jang S., Matsunami H., Sekharan S., Dethier B., Ertem M.Z.,
RA Gundala S., Pan Y., Li S., Li Z., Lodge S.N., Ozbil M., Jiang H.,
RA Penalba S.F., Batista V.S., Zhuang H.;
RT "Implausibility of the vibrational theory of olfaction.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E2766-E2774(2015).
CC -!- FUNCTION: Odorant receptor involved in the detection of muscone,
CC cyclopentadecanone, cyclopentadecanol, and omega-pentadecalactone
CC (PubMed:24361078, PubMed:25901328). The activity of this receptor is
CC mediated by G proteins which activate adenylyl cyclase (Probable).
CC {ECO:0000269|PubMed:24361078, ECO:0000269|PubMed:25901328,
CC ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:24361078,
CC ECO:0000305|PubMed:25901328}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AN1";
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DR EMBL; AB065806; BAC06025.1; -; Genomic_DNA.
DR EMBL; BC140917; AAI40918.1; -; mRNA.
DR EMBL; BK004508; DAA04906.1; -; Genomic_DNA.
DR CCDS; CCDS31559.1; -.
DR RefSeq; NP_001004729.1; NM_001004729.1.
DR AlphaFoldDB; Q8NGI8; -.
DR SMR; Q8NGI8; -.
DR STRING; 9606.ENSP00000320302; -.
DR GlyGen; Q8NGI8; 1 site.
DR BioMuta; OR5AN1; -.
DR DMDM; 38372701; -.
DR MassIVE; Q8NGI8; -.
DR PaxDb; Q8NGI8; -.
DR PeptideAtlas; Q8NGI8; -.
DR PRIDE; Q8NGI8; -.
DR Antibodypedia; 58819; 81 antibodies from 20 providers.
DR DNASU; 390195; -.
DR Ensembl; ENST00000313940.2; ENSP00000320302.2; ENSG00000176495.3.
DR Ensembl; ENST00000641850.1; ENSP00000492957.1; ENSG00000176495.3.
DR Ensembl; ENST00000641998.1; ENSP00000493250.1; ENSG00000176495.3.
DR GeneID; 390195; -.
DR KEGG; hsa:390195; -.
DR MANE-Select; ENST00000641998.1; ENSP00000493250.1; NM_001004729.2; NP_001004729.1.
DR UCSC; uc010rks.3; human.
DR CTD; 390195; -.
DR DisGeNET; 390195; -.
DR GeneCards; OR5AN1; -.
DR HGNC; HGNC:15255; OR5AN1.
DR HPA; ENSG00000176495; Not detected.
DR MIM; 615702; gene.
DR neXtProt; NX_Q8NGI8; -.
DR OpenTargets; ENSG00000176495; -.
DR PharmGKB; PA32466; -.
DR VEuPathDB; HostDB:ENSG00000176495; -.
DR eggNOG; ENOG502TM2A; Eukaryota.
DR GeneTree; ENSGT01050000244931; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGI8; -.
DR OMA; YITSLTW; -.
DR OrthoDB; 1141580at2759; -.
DR PhylomeDB; Q8NGI8; -.
DR TreeFam; TF352755; -.
DR PathwayCommons; Q8NGI8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390195; 12 hits in 669 CRISPR screens.
DR GeneWiki; OR5AN1; -.
DR GenomeRNAi; 390195; -.
DR Pharos; Q8NGI8; Tdark.
DR PRO; PR:Q8NGI8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGI8; protein.
DR ExpressionAtlas; Q8NGI8; differential.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IDA:UniProtKB.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 5AN1"
FT /id="PRO_0000150577"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 289
FT /note="L -> F (in dbSNP:rs7941190)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024098"
SQ SEQUENCE 311 AA; 34789 MW; 31F86526CC4C869B CRC64;
MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI RMDSHLHTPM
YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII QYFIFSTMGL SESCLMTAMA
YDRYAAICNP LLYSSIMSPT LCVWMVLGAY MTGLTASLFQ IGALLQLHFC GSNVIRHFFC
DMPQLLILSC TDTFFVQVMT AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN
TCASHLTAVS LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD
ALKRLQKRKC C
