O5AP2_HUMAN
ID O5AP2_HUMAN Reviewed; 316 AA.
AC Q8NGF4; B2RNM8;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 5AP2;
GN Name=OR5AP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AP2";
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DR EMBL; AB065854; BAC06072.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73720.1; -; Genomic_DNA.
DR EMBL; BC136989; AAI36990.1; -; mRNA.
DR CCDS; CCDS31534.1; -.
DR RefSeq; NP_001002925.1; NM_001002925.1.
DR AlphaFoldDB; Q8NGF4; -.
DR SMR; Q8NGF4; -.
DR BioGRID; 130780; 4.
DR STRING; 9606.ENSP00000303111; -.
DR GlyGen; Q8NGF4; 1 site.
DR PhosphoSitePlus; Q8NGF4; -.
DR BioMuta; OR5AP2; -.
DR DMDM; 37081351; -.
DR PaxDb; Q8NGF4; -.
DR PeptideAtlas; Q8NGF4; -.
DR PRIDE; Q8NGF4; -.
DR Antibodypedia; 58995; 55 antibodies from 16 providers.
DR DNASU; 338675; -.
DR Ensembl; ENST00000544374.3; ENSP00000442701.2; ENSG00000172464.4.
DR GeneID; 338675; -.
DR KEGG; hsa:338675; -.
DR MANE-Select; ENST00000544374.3; ENSP00000442701.2; NM_001002925.1; NP_001002925.1.
DR UCSC; uc001njb.1; human.
DR CTD; 338675; -.
DR DisGeNET; 338675; -.
DR GeneCards; OR5AP2; -.
DR HGNC; HGNC:15258; OR5AP2.
DR HPA; ENSG00000172464; Not detected.
DR neXtProt; NX_Q8NGF4; -.
DR PharmGKB; PA32469; -.
DR VEuPathDB; HostDB:ENSG00000172464; -.
DR eggNOG; ENOG502RF13; Eukaryota.
DR GeneTree; ENSGT01050000244954; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NGF4; -.
DR OMA; VRGRNQT; -.
DR OrthoDB; 1171129at2759; -.
DR PhylomeDB; Q8NGF4; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGF4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 338675; 4 hits in 669 CRISPR screens.
DR GenomeRNAi; 338675; -.
DR Pharos; Q8NGF4; Tdark.
DR PRO; PR:Q8NGF4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGF4; protein.
DR Bgee; ENSG00000172464; Expressed in reproductive system and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 5AP2"
FT /id="PRO_0000150578"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 103..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 105
FT /note="A -> T (in dbSNP:rs11606499)"
FT /id="VAR_053180"
SQ SEQUENCE 316 AA; 35508 MW; 5C2A3D9B7482400C CRC64;
MRLMKEVRGR NQTEVTEFLL LGLSDNPDLQ GVLFALFLLI YMANMVGNLG MIVLIKIDLC
LHTPMYFFLS SLSFVDASYS SSVTPKMLVN LMAENKAISF HGCAAQFYFF GSFLGTECFL
LAMMAYDRYA AIWNPLLYPV LVSGRICFLL IATSFLAGCG NAAIHTGMTF RLSFCGSNRI
NHFYCDTPPL LKLSCSDTHF NGIVIMAFSS FIVISCVMIV LISYLCIFIA VLKMPSLEGR
HKAFSTCASY LMAVTIFFGT ILFMYLRPTS SYSMEQDKVV SVFYTVIIPV LNPLIYSLKN
KDVKKALKKI LWKHIL
