O5AR1_HUMAN
ID O5AR1_HUMAN Reviewed; 310 AA.
AC Q8NGP9; Q6IF61;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 5AR1;
DE AltName: Full=Olfactory receptor OR11-209;
GN Name=OR5AR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [4]
RP POLYMORPHISM.
RX PubMed=17973576; DOI=10.1371/journal.pbio.0050284;
RA Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W.,
RA Lancet D.;
RT "Genetic elucidation of human hyperosmia to isovaleric acid.";
RL PLoS Biol. 5:2462-2468(2007).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon in the gene coding for this protein at
CC position Gln-19 is responsible for functional diversity thus producing
CC a pseudogene.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AR1";
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DR EMBL; AB065740; BAC05961.1; -; Genomic_DNA.
DR EMBL; BK004401; DAA04799.1; -; Genomic_DNA.
DR RefSeq; NP_001004730.1; NM_001004730.1.
DR AlphaFoldDB; Q8NGP9; -.
DR SMR; Q8NGP9; -.
DR STRING; 9606.ENSP00000485424; -.
DR GlyGen; Q8NGP9; 1 site.
DR iPTMnet; Q8NGP9; -.
DR PhosphoSitePlus; Q8NGP9; -.
DR BioMuta; OR5AR1; -.
DR DMDM; 37081363; -.
DR MassIVE; Q8NGP9; -.
DR PaxDb; Q8NGP9; -.
DR PRIDE; Q8NGP9; -.
DR Antibodypedia; 78755; 46 antibodies from 14 providers.
DR DNASU; 219493; -.
DR Ensembl; ENST00000624596.2; ENSP00000485240.1; ENSG00000172459.5.
DR GeneID; 219493; -.
DR KEGG; hsa:219493; -.
DR MANE-Select; ENST00000624596.2; ENSP00000485240.1; NM_001004730.1; NP_001004730.1.
DR UCSC; uc010rjm.2; human.
DR CTD; 219493; -.
DR GeneCards; OR5AR1; -.
DR HGNC; HGNC:15260; OR5AR1.
DR HPA; ENSG00000172459; Not detected.
DR neXtProt; NX_Q8NGP9; -.
DR PharmGKB; PA32471; -.
DR VEuPathDB; HostDB:ENSG00000172459; -.
DR eggNOG; ENOG502SHXT; Eukaryota.
DR GeneTree; ENSGT01050000244954; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGP9; -.
DR OMA; TGITQDP; -.
DR OrthoDB; 963494at2759; -.
DR PhylomeDB; Q8NGP9; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGP9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219493; 14 hits in 667 CRISPR screens.
DR GeneWiki; OR5AR1; -.
DR GenomeRNAi; 219493; -.
DR Pharos; Q8NGP9; Tdark.
DR PRO; PR:Q8NGP9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGP9; protein.
DR ExpressionAtlas; Q8NGP9; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 5AR1"
FT /id="PRO_0000150579"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 225
FT /note="I -> V (in dbSNP:rs56067375)"
FT /id="VAR_062038"
SQ SEQUENCE 310 AA; 34815 MW; 660D5C566B330E47 CRC64;
MDKENSSMVT EFIFMGITQD PQMEIIFFVV FLIVYLVNVV GNIGMIILIT TDTQLHTPMY
FFLCNLSFVD LGYSSAIAPR MLADFLTNHK VISFSSCATQ FAFFVGFVDA ECYVLAAMAY
GRFVAICRPL HYSTFMSKQV CLALMLGSYL AGLVSLVAHT TLTFSLSYCG SNIINHFFCE
IPPLLALSCS DTYISEILLF SLCGFIEFST ILIIFISYTF ILVAIIRMRS AEGRLKAFST
CGSHLTGITL FYGTVMFMYL RPTSSYSLDQ DKWASVFYTV IIPMLNPLIY SLRNKDVKAA
FKKLIGKKSQ
