O5AS1_HUMAN
ID O5AS1_HUMAN Reviewed; 324 AA.
AC Q8N127; Q6IFB8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 5AS1;
DE AltName: Full=Olfactory receptor OR11-168;
GN Name=OR5AS1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q8N127; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-19949977, EBI-17208936;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AS1";
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DR EMBL; AB065452; BAC05714.1; -; Genomic_DNA.
DR EMBL; AB065543; BAC05788.1; -; Genomic_DNA.
DR EMBL; BK004344; DAA04742.1; -; Genomic_DNA.
DR CCDS; CCDS31516.1; -.
DR RefSeq; NP_001001921.1; NM_001001921.1.
DR AlphaFoldDB; Q8N127; -.
DR SMR; Q8N127; -.
DR BioGRID; 128538; 1.
DR IntAct; Q8N127; 1.
DR STRING; 9606.ENSP00000324111; -.
DR GlyGen; Q8N127; 1 site.
DR BioMuta; OR5AS1; -.
DR DMDM; 38372640; -.
DR PaxDb; Q8N127; -.
DR PeptideAtlas; Q8N127; -.
DR PRIDE; Q8N127; -.
DR Antibodypedia; 58956; 94 antibodies from 20 providers.
DR DNASU; 219447; -.
DR Ensembl; ENST00000641320.1; ENSP00000493325.1; ENSG00000181785.3.
DR GeneID; 219447; -.
DR KEGG; hsa:219447; -.
DR MANE-Select; ENST00000641320.1; ENSP00000493325.1; NM_001001921.2; NP_001001921.1.
DR UCSC; uc010riw.2; human.
DR CTD; 219447; -.
DR GeneCards; OR5AS1; -.
DR HGNC; HGNC:15261; OR5AS1.
DR HPA; ENSG00000181785; Tissue enhanced (brain).
DR neXtProt; NX_Q8N127; -.
DR PharmGKB; PA32472; -.
DR VEuPathDB; HostDB:ENSG00000181785; -.
DR eggNOG; ENOG502RF3K; Eukaryota.
DR GeneTree; ENSGT01050000244954; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8N127; -.
DR OMA; RRVCICF; -.
DR OrthoDB; 980883at2759; -.
DR PhylomeDB; Q8N127; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8N127; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219447; 12 hits in 637 CRISPR screens.
DR GeneWiki; OR5AS1; -.
DR GenomeRNAi; 219447; -.
DR Pharos; Q8N127; Tdark.
DR PRO; PR:Q8N127; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N127; protein.
DR ExpressionAtlas; Q8N127; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 5AS1"
FT /id="PRO_0000150580"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 122
FT /note="R -> L (in dbSNP:rs12224086)"
FT /id="VAR_034217"
FT VARIANT 310
FT /note="Y -> C (in dbSNP:rs17600939)"
FT /id="VAR_034218"
SQ SEQUENCE 324 AA; 36653 MW; 5EFC9C27B061594E CRC64;
MLESNYTMPT EFLFVGFTDY LPLRVTLFLV FLLVYTLTMV GNILLIILVN INSSLQIPMY
YFLSNLSFLD ISCSTAITPK MLANFLASRK SISPYGCALQ MFFFASFADA ECLILAAMAY
DRYAAICNPL LYTTLMSRRV CVCFIVLAYF SGSTTSLVHV CLTFRLSFCG SNIVNHFFCD
IPPLLALSCT DTQINQLLLF ALCSFIQTST FVVIFISYFC ILITVLSIKS SGGRSKTFST
CASHLIAVTL FYGALLFMYL QPTTSYSLDT DKVVAVFYTV VFPMFNPIIY SFRNKDVKNA
LKKLLERIGY SNEWYLNRLR IVNI
