O5H15_HUMAN
ID O5H15_HUMAN Reviewed; 313 AA.
AC A6NDH6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Olfactory receptor 5H15;
GN Name=OR5H15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5H15";
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DR EMBL; AC117460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33799.1; -.
DR RefSeq; NP_001005515.1; NM_001005515.1.
DR AlphaFoldDB; A6NDH6; -.
DR SMR; A6NDH6; -.
DR STRING; 9606.ENSP00000373195; -.
DR GlyGen; A6NDH6; 1 site.
DR iPTMnet; A6NDH6; -.
DR PhosphoSitePlus; A6NDH6; -.
DR BioMuta; OR5H15; -.
DR MassIVE; A6NDH6; -.
DR PaxDb; A6NDH6; -.
DR PeptideAtlas; A6NDH6; -.
DR PRIDE; A6NDH6; -.
DR Antibodypedia; 58696; 52 antibodies from 16 providers.
DR DNASU; 403274; -.
DR Ensembl; ENST00000641450.1; ENSP00000493082.1; ENSG00000233412.6.
DR GeneID; 403274; -.
DR KEGG; hsa:403274; -.
DR MANE-Select; ENST00000641450.1; ENSP00000493082.1; NM_001005515.2; NP_001005515.1.
DR UCSC; uc011bgu.2; human.
DR CTD; 403274; -.
DR GeneCards; OR5H15; -.
DR HGNC; HGNC:31287; OR5H15.
DR HPA; ENSG00000233412; Not detected.
DR neXtProt; NX_A6NDH6; -.
DR PharmGKB; PA134956122; -.
DR VEuPathDB; HostDB:ENSG00000233412; -.
DR eggNOG; ENOG502T9JQ; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; A6NDH6; -.
DR OMA; LIAVTWK; -.
DR OrthoDB; 865116at2759; -.
DR PhylomeDB; A6NDH6; -.
DR TreeFam; TF352737; -.
DR PathwayCommons; A6NDH6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; A6NDH6; -.
DR BioGRID-ORCS; 403274; 8 hits in 583 CRISPR screens.
DR GenomeRNAi; 403274; -.
DR Pharos; A6NDH6; Tdark.
DR PRO; PR:A6NDH6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6NDH6; protein.
DR ExpressionAtlas; A6NDH6; differential.
DR Genevisible; A6NDH6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 5H15"
FT /id="PRO_0000310413"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 108
FT /note="V -> I (in dbSNP:rs4133320)"
FT /id="VAR_037027"
FT VARIANT 148
FT /note="S -> T (in dbSNP:rs4133321)"
FT /id="VAR_037028"
FT VARIANT 167
FT /note="T -> S (in dbSNP:rs4133322)"
FT /id="VAR_037029"
SQ SEQUENCE 313 AA; 35352 MW; 1298D50481425F26 CRC64;
MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW KDPHLHIPMY
LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ FFSIAIGVTT ECFLLATMAY
DRYVAICKPL LYPAIMTNGL CIRLLILSYI AGILHALIHE GFLFRLTFCN SNIVHHIYCD
TIPLSKISCT DSSINFLMVF IFSGSIQVFS IVTILISYTF VLFTVLEKKS DKGVRKAFST
CGAHLFSVCL YYGPLLLMYV GPASPQADGQ NMVEPLFYTV IIPLLNPIIY SLRNKQVIVS
FIKMLKRNVK VSY
