O7E24_HUMAN
ID O7E24_HUMAN Reviewed; 339 AA.
AC Q6IFN5; B9EJD9; Q9UPJ1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Olfactory receptor 7E24;
DE AltName: Full=Olfactory receptor OR19-14;
GN Name=OR7E24; Synonyms=OR7E24P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD03353.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7E24";
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DR EMBL; AC006271; AAD03353.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC146920; AAI46921.1; -; mRNA.
DR EMBL; BK004227; DAA04625.1; -; Genomic_DNA.
DR CCDS; CCDS45955.1; -.
DR RefSeq; NP_001073404.1; NM_001079935.1.
DR AlphaFoldDB; Q6IFN5; -.
DR SMR; Q6IFN5; -.
DR BioGRID; 117773; 1.
DR STRING; 9606.ENSP00000387523; -.
DR GlyGen; Q6IFN5; 1 site.
DR iPTMnet; Q6IFN5; -.
DR PhosphoSitePlus; Q6IFN5; -.
DR BioMuta; OR7E24; -.
DR DMDM; 74757943; -.
DR MassIVE; Q6IFN5; -.
DR PaxDb; Q6IFN5; -.
DR PRIDE; Q6IFN5; -.
DR Antibodypedia; 68428; 26 antibodies from 15 providers.
DR DNASU; 26648; -.
DR Ensembl; ENST00000456448.3; ENSP00000387523.1; ENSG00000237521.4.
DR GeneID; 26648; -.
DR KEGG; hsa:26648; -.
DR MANE-Select; ENST00000456448.3; ENSP00000387523.1; NM_001079935.2; NP_001073404.1.
DR UCSC; uc002mlb.2; human.
DR CTD; 26648; -.
DR GeneCards; OR7E24; -.
DR HGNC; HGNC:8396; OR7E24.
DR HPA; ENSG00000237521; Tissue enriched (testis).
DR neXtProt; NX_Q6IFN5; -.
DR OpenTargets; ENSG00000237521; -.
DR PharmGKB; PA32675; -.
DR VEuPathDB; HostDB:ENSG00000237521; -.
DR eggNOG; ENOG502T9MT; Eukaryota.
DR GeneTree; ENSGT00940000153277; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q6IFN5; -.
DR OMA; PRKDMVA; -.
DR OrthoDB; 1088794at2759; -.
DR PhylomeDB; Q6IFN5; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q6IFN5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26648; 9 hits in 673 CRISPR screens.
DR GenomeRNAi; 26648; -.
DR Pharos; Q6IFN5; Tdark.
DR PRO; PR:Q6IFN5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6IFN5; protein.
DR Bgee; ENSG00000237521; Expressed in oocyte and 8 other tissues.
DR ExpressionAtlas; Q6IFN5; baseline and differential.
DR Genevisible; Q6IFN5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..339
FT /note="Olfactory receptor 7E24"
FT /id="PRO_0000281642"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..215
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 115..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 193
FT /note="S -> F (in dbSNP:rs12980833)"
FT /id="VAR_053236"
FT VARIANT 242
FT /note="P -> S (in dbSNP:rs2240928)"
FT /id="VAR_053237"
SQ SEQUENCE 339 AA; 38279 MW; 529D5BAB05301A24 CRC64;
MSYFPILFFF FLKRCPSYTE PQNLTGVSEF LLLGLSEDPE LQPVLAGLFL SMYLVTVLGN
LLIILAVSSD SHLHTPMYFF LSNLSLADIG FTSTTVPKMI VDMQTHSRVI SYEGCLTQMS
FFVLFACMDD MLLSVMAYDR FVAICHPLHY RIIMNPRLCG FLILLSFFIS LLDSQLHNLI
MLQLTCFKDV DISNFFCDPS QLLHLRCSDT FINEMVIYFM GAIFGCLPIS GILFSYYKIV
SPILRVPTSD GKYKAFSTCG SHLAVVCLFY GTGLVGYLSS AVLPSPRKSM VASVMYTVVT
PMLNPFIYSL RNKDIQSALC RLHGRIIKSH HLHPFCYMG
