O8G2P_HUMAN
ID O8G2P_HUMAN Reviewed; 304 AA.
AC Q6IF36; Q15614; Q6IF38;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Putative olfactory receptor 8G2 {ECO:0000305};
DE AltName: Full=Olfactory receptor 8G4 {ECO:0000305};
DE AltName: Full=Olfactory receptor OR11-292 {ECO:0000303|PubMed:14983052};
DE AltName: Full=Olfactory receptor TPCR120;
GN Name=OR8G2P {ECO:0000312|HGNC:HGNC:8485};
GN Synonyms=OR8G2 {ECO:0000312|HGNC:HGNC:8485},
GN OR8G4 {ECO:0000312|HGNC:HGNC:8485};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 139-295.
RC TISSUE=Testis;
RX PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT "Specific repertoire of olfactory receptor genes in the male germ cells of
RT several mammalian species.";
RL Genomics 39:239-246(1997).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8G2P";
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DR EMBL; FO680687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136638; AAI36639.1; -; mRNA.
DR EMBL; X89669; CAA61816.1; -; mRNA.
DR EMBL; BK004426; DAA04824.1; -; Genomic_DNA.
DR RefSeq; NP_001278367.1; NM_001291438.1.
DR AlphaFoldDB; Q6IF36; -.
DR SMR; Q6IF36; -.
DR GlyGen; Q6IF36; 1 site.
DR BioMuta; HGNC:8485; -.
DR jPOST; Q6IF36; -.
DR PRIDE; Q6IF36; -.
DR DNASU; 26492; -.
DR GeneID; 26492; -.
DR CTD; 26492; -.
DR GeneCards; OR8G2P; -.
DR HGNC; HGNC:8485; OR8G2P.
DR neXtProt; NX_Q6IF36; -.
DR OrthoDB; 1045425at2759; -.
DR PathwayCommons; Q6IF36; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26492; 12 hits in 165 CRISPR screens.
DR GenomeRNAi; 26492; -.
DR Pharos; Q6IF36; Tdark.
DR PRO; PR:Q6IF36; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6IF36; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..304
FT /note="Putative olfactory receptor 8G2"
FT /id="PRO_0000432917"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..110
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 111..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..193
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 218..238
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..257
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 258..278
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 110..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 163
FT /note="V -> I (in Ref. 3; CAA61816)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="V -> G (in Ref. 3; CAA61816)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="R -> G (in Ref. 3; CAA61816)"
FT /evidence="ECO:0000305"
FT CONFLICT 293..294
FT /note="TI -> IV (in Ref. 3; CAA61816)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 304 AA; 33950 MW; 10AC56A58121CBA7 CRC64;
MVFLSSVETD QRKMSAGNHS SVTEFILAGL SEQPELQLRL FLLFLGIYVV TVVGNLSMIT
LIGLSSHLHT PMYYFLSGLS FIDLCHSTII TPKMLVNFVT EKNIISYPEC MTQLYFFLIF
AIAECHMLAV TAYDRYVAIC SPLLYNVIMS YHHCFWLTVG VYVLGILGST IHTGFMLRLF
LCKTNVINHY FCDLFPLLGL SCSSTYINEL LVLVLSAFNI LTPALTILAS YIFIIASILR
IRSTEGRSKA FSTCSSHILA VAVFFGSAAF MYLQPSSVSS MDQRKVSSVF YTTIVPMLNP
QSIA
