OAC1_YEAST
ID OAC1_YEAST Reviewed; 324 AA.
AC P32332; D6VXH0;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Mitochondrial oxaloacetate transport protein;
DE AltName: Full=Mitochondrial carrier protein PMT;
GN Name=OAC1; Synonyms=PMT, PMT1; OrderedLocusNames=YKL120W; ORFNames=YKL522;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 26109 / X2180;
RA Bachhawat A.K., Jones E.W.;
RT "Sequence and disruption analysis of a putative mitochondrial transporter
RT protein gene.";
RL Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC STRAIN=ATCC 96099 / S288c / SEY6210;
RX PubMed=10428783; DOI=10.1074/jbc.274.32.22184;
RA Palmieri L., Vozza A., Agrimi G., De Marco V., Runswick M.J., Palmieri F.,
RA Walker J.E.;
RT "Identification of the yeast mitochondrial transporter for oxaloacetate and
RT sulfate.";
RL J. Biol. Chem. 274:22184-22190(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1514329; DOI=10.1002/yea.320080410;
RA Colleaux L., Richard G.-F., Thierry A., Dujon B.;
RT "Sequence of a segment of yeast chromosome XI identifies a new
RT mitochondrial carrier, a new member of the G protein family, and a protein
RT with the PAAKK motif of the H1 histones.";
RL Yeast 8:325-336(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Transports oxaloacetate and sulfate.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 5350 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; L04948; AAA34886.1; -; Genomic_DNA.
DR EMBL; AJ238698; CAB52216.1; -; Genomic_DNA.
DR EMBL; S44213; AAB23071.2; -; Genomic_DNA.
DR EMBL; Z28120; CAA81961.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09040.1; -; Genomic_DNA.
DR PIR; S25357; S25357.
DR RefSeq; NP_012802.1; NM_001179686.1.
DR AlphaFoldDB; P32332; -.
DR SMR; P32332; -.
DR BioGRID; 34015; 101.
DR DIP; DIP-5417N; -.
DR IntAct; P32332; 5.
DR MINT; P32332; -.
DR STRING; 4932.YKL120W; -.
DR TCDB; 2.A.29.15.1; the mitochondrial carrier (mc) family.
DR MaxQB; P32332; -.
DR PaxDb; P32332; -.
DR PRIDE; P32332; -.
DR EnsemblFungi; YKL120W_mRNA; YKL120W; YKL120W.
DR GeneID; 853739; -.
DR KEGG; sce:YKL120W; -.
DR SGD; S000001603; OAC1.
DR VEuPathDB; FungiDB:YKL120W; -.
DR eggNOG; KOG0755; Eukaryota.
DR GeneTree; ENSGT00940000160771; -.
DR HOGENOM; CLU_015166_14_3_1; -.
DR InParanoid; P32332; -.
DR OMA; VMSRMYN; -.
DR BioCyc; YEAST:G3O-31903-MON; -.
DR PRO; PR:P32332; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P32332; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0034658; F:isopropylmalate transmembrane transporter activity; IDA:SGD.
DR GO; GO:1901239; F:malonate(1-) transmembrane transporter activity; IDA:SGD.
DR GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IDA:SGD.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IDA:SGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0034659; P:isopropylmalate transport; IDA:SGD.
DR GO; GO:0015729; P:oxaloacetate transport; IDA:SGD.
DR GO; GO:0008272; P:sulfate transport; IDA:SGD.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..324
FT /note="Mitochondrial oxaloacetate transport protein"
FT /id="PRO_0000090689"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..305
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 20..111
FT /note="Solcar 1"
FT REPEAT 126..218
FT /note="Solcar 2"
FT REPEAT 227..312
FT /note="Solcar 3"
SQ SEQUENCE 324 AA; 35153 MW; 696193F8979266AE CRC64;
MSSDNSKQDK QIEKTAAQKI SKFGSFVAGG LAACIAVTVT NPIELIKIRM QLQGEMSASA
AKVYKNPIQG MAVIFKNEGI KGLQKGLNAA YIYQIGLNGS RLGFYEPIRS SLNQLFFPDQ
EPHKVQSVGV NVFSGAASGI IGAVIGSPLF LVKTRLQSYS EFIKIGEQTH YTGVWNGLVT
IFKTEGVKGL FRGIDAAILR TGAGSSVQLP IYNTAKNILV KNDLMKDGPA LHLTASTISG
LGVAVVMNPW DVILTRIYNQ KGDLYKGPID CLVKTVRIEG VTALYKGFAA QVFRIAPHTI
MCLTFMEQTM KLVYSIESRV LGHN
