OACYL_MOUSE
ID OACYL_MOUSE Reviewed; 685 AA.
AC Q8BML2; B9EJ12; E9Q6M1; Q8BMK8;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=O-acyltransferase like protein {ECO:0000305};
DE AltName: Full=Protein oacyl {ECO:0000305};
DE Flags: Precursor;
GN Name=Oacyl {ECO:0000312|MGI:MGI:2442915};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BML2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BML2-2; Sequence=VSP_058597;
CC -!- SIMILARITY: Belongs to the acyltransferase 3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK030604; BAC27041.1; -; mRNA.
DR EMBL; AK030615; BAC27048.1; -; mRNA.
DR EMBL; AC124578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC141265; AAI41266.1; -; mRNA.
DR CCDS; CCDS29308.1; -. [Q8BML2-1]
DR RefSeq; NP_796002.1; NM_177028.3. [Q8BML2-1]
DR AlphaFoldDB; Q8BML2; -.
DR STRING; 10090.ENSMUSP00000110749; -.
DR PaxDb; Q8BML2; -.
DR PRIDE; Q8BML2; -.
DR DNASU; 319888; -.
DR Ensembl; ENSMUST00000115097; ENSMUSP00000110749; ENSMUSG00000046610. [Q8BML2-1]
DR Ensembl; ENSMUST00000117694; ENSMUSP00000113626; ENSMUSG00000046610. [Q8BML2-2]
DR GeneID; 319888; -.
DR KEGG; mmu:319888; -.
DR UCSC; uc008ffg.1; mouse. [Q8BML2-1]
DR CTD; 319888; -.
DR MGI; MGI:2442915; Oacyl.
DR VEuPathDB; HostDB:ENSMUSG00000046610; -.
DR eggNOG; KOG3700; Eukaryota.
DR GeneTree; ENSGT00530000063340; -.
DR HOGENOM; CLU_007874_3_1_1; -.
DR InParanoid; Q8BML2; -.
DR OMA; QPLHMYS; -.
DR OrthoDB; 1171418at2759; -.
DR PhylomeDB; Q8BML2; -.
DR TreeFam; TF313063; -.
DR BioGRID-ORCS; 319888; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Oacyl; mouse.
DR PRO; PR:Q8BML2; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8BML2; protein.
DR Bgee; ENSMUSG00000046610; Expressed in animal zygote and 32 other tissues.
DR ExpressionAtlas; Q8BML2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR InterPro; IPR002656; Acyl_transf_3_dom.
DR InterPro; IPR006621; Nose-resist-to-fluoxetine_N.
DR Pfam; PF01757; Acyl_transf_3; 1.
DR Pfam; PF20146; NRF; 1.
DR SMART; SM00703; NRF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..685
FT /note="O-acyltransferase like protein"
FT /evidence="ECO:0000255"
FT /id="PRO_5007927424"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 538..558
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 607..627
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 50..123
FT /note="MYDSVGKLGSNVLTGNVDRLGSYSECLSTRSPKGSFRGQYCKLHILQDGTDY
FT SVGVCVPDSCAEEDVTMMSQLG -> S (in isoform 2)"
FT /id="VSP_058597"
FT CONFLICT 163
FT /note="M -> V (in Ref. 3; AAI41266)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="P -> Q (in Ref. 1; BAC27048)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="C -> S (in Ref. 3; AAI41266)"
FT /evidence="ECO:0000305"
FT CONFLICT 442
FT /note="T -> M (in Ref. 3; AAI41266)"
FT /evidence="ECO:0000305"
FT CONFLICT 456..457
FT /note="VF -> AL (in Ref. 3; AAI41266)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 685 AA; 76543 MW; CC588BA0A38EA36A CRC64;
MMALTSLACL HALFPFVSPA RNISLKCMQD TDEFLSDLNS LKPKEYALRM YDSVGKLGSN
VLTGNVDRLG SYSECLSTRS PKGSFRGQYC KLHILQDGTD YSVGVCVPDS CAEEDVTMMS
QLGTLKFRNT SFLEPSLSLF TKDSSSSCEV VARCAAGAMS PDMFASVCLF ITLLGLVLPV
AGTVYMVARD WGLDLRTSSV HGTPPTSCES LPLRNMESNR QRSRASCQVQ LPPPGAPSRG
RRFLGAVDEV LQCFSWQKNM PAICSPELPG GTCRTLNGIR VLSLLWVISG HTSQMTAWLS
LDNVLEWKSR VPENPLYLYS RSGPFYLGVD TFFLISGWLS ARSFLKMHQN TSTGITPKVI
LRYFLKRFTR LQLLHMYSVC LLVGFFSFVP WGPVWEVAQF HWDNCREVWW TNLLLLNNFL
SVQNACNGWT WYLASDFQFH LTTPLIFFVH GKSKRVFVLL GGLLFLASST ATTLLTLAYK
LPVASPAAAS EHGTVLYFSE YYTKPYCRCG PFLVGLFLSM FMHSDHPTDI LKTTVQAMLG
WTWSLLTLFA VVALAYVLDD TSPTSSVAAA IYQALHRTLW AAAVGWVIFA CQEGYGGPVK
RMLSWGIWSL PASISYACYL VHPIVIILYN GLQETLIHYT DTNMLYLFFG HCVLTFLGGL
VLTLFIERPW QELKWGLWGP EPARP
