OADB2_SALTI
ID OADB2_SALTI Reviewed; 433 AA.
AC Q8Z3E5; Q83SW0;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Oxaloacetate decarboxylase beta chain 2;
DE EC=7.2.4.2;
GN Name=oadB2; Synonyms=oadB; OrderedLocusNames=STY3531, t3266;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Catalyzes the decarboxylation of oxaloacetate coupled to
CC Na(+) translocation.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) +
CC pyruvate; Xref=Rhea:RHEA:57724, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16526, ChEBI:CHEBI:29101; EC=7.2.4.2;
CC -!- COFACTOR:
CC Name=Na(+); Xref=ChEBI:CHEBI:29101;
CC -!- SUBUNIT: Heterotrimer of an alpha, a beta and a gamma subunit.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the GcdB/MmdB/OadB family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL513382; CAD07866.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70801.1; -; Genomic_DNA.
DR RefSeq; NP_457727.1; NC_003198.1.
DR RefSeq; WP_000444843.1; NZ_QGFE01000135.1.
DR AlphaFoldDB; Q8Z3E5; -.
DR SMR; Q8Z3E5; -.
DR STRING; 220341.16504413; -.
DR PRIDE; Q8Z3E5; -.
DR EnsemblBacteria; AAO70801; AAO70801; t3266.
DR KEGG; stt:t3266; -.
DR KEGG; sty:STY3531; -.
DR PATRIC; fig|220341.7.peg.3595; -.
DR eggNOG; COG1883; Bacteria.
DR HOGENOM; CLU_036168_0_0_6; -.
DR OMA; PMIADPK; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015451; F:decarboxylation-driven active transmembrane transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR005661; OadB_MmdB.
DR PANTHER; PTHR35806; PTHR35806; 1.
DR Pfam; PF03977; OAD_beta; 1.
DR PIRSF; PIRSF015658; MmdB_OadB; 1.
DR TIGRFAMs; TIGR01109; Na_pump_decarbB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Sodium; Sodium transport;
KW Translocase; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..433
FT /note="Oxaloacetate decarboxylase beta chain 2"
FT /id="PRO_0000232700"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 339
FT /note="T -> M (in Ref. 2; AAO70801)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 433 AA; 44964 MW; 8B1DC8DF49584357 CRC64;
MESLNALLQG MGLMHLGAGQ AIMLLVSLLL LWLAIAKKFE PLLLLPIGFG GLLSNIPEAG
MALTALESLL AHHDAGQLAV IAAKLNCAPD VHAIKEALAL ALPSVQNQME NLAVDMGYTP
GVLALFYKVA IGSGVAPLVI FMGVGAMTDF GPLLANPRTL LLGAAAQFGI FATVLGALTL
NYFGLIAFTL PQAAAIGIIG GADGPTAIYL SGKLAPELLG AIAVAAYSYM ALVPLIQPPI
MRALTSEKER KIRMVQLRTV SKREKILFPV VLLLLVALLL PDAAPLLGMF CFGNLMRESG
VVERLSDTVQ NGLINIVTIF LGLSVGAKLV ADKFLQPQTL GILLLGVIAF GIGTAAGVLM
AKLLNLCSKN KINPLIGSAG VSAVPMAARV SNKVGLESNP QNFLLMHAMG PNVAGVIGSA
IAAGVMLKYV LAM
