ID   OADB_VIBCH              Reviewed;         433 AA.
AC   Q9KTU5;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable oxaloacetate decarboxylase beta chain;
DE            EC=7.2.4.2;
GN   Name=oadB; OrderedLocusNames=VC_0792;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Catalyzes the decarboxylation of oxaloacetate coupled to
CC       Na(+) translocation. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) +
CC         pyruvate; Xref=Rhea:RHEA:57724, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16526, ChEBI:CHEBI:29101; EC=7.2.4.2;
CC   -!- COFACTOR:
CC       Name=Na(+); Xref=ChEBI:CHEBI:29101; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Heterotrimer of an alpha, a beta and a gamma subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GcdB/MmdB/OadB family. {ECO:0000305}.
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DR   EMBL; AE003852; AAF93957.1; -; Genomic_DNA.
DR   PIR; D82280; D82280.
DR   RefSeq; NP_230441.1; NC_002505.1.
DR   RefSeq; WP_000427751.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KTU5; -.
DR   SMR; Q9KTU5; -.
DR   STRING; 243277.VC_0792; -.
DR   TCDB; 3.B.1.1.6; the na(+)-transporting carboxylic acid decarboxylase (nat-dc) family.
DR   PRIDE; Q9KTU5; -.
DR   DNASU; 2615335; -.
DR   EnsemblBacteria; AAF93957; AAF93957; VC_0792.
DR   GeneID; 57739500; -.
DR   KEGG; vch:VC_0792; -.
DR   PATRIC; fig|243277.26.peg.754; -.
DR   eggNOG; COG1883; Bacteria.
DR   HOGENOM; CLU_036168_0_0_6; -.
DR   OMA; PMIADPK; -.
DR   BioCyc; VCHO:VC0792-MON; -.
DR   PHI-base; PHI:7640; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015451; F:decarboxylation-driven active transmembrane transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005661; OadB_MmdB.
DR   PANTHER; PTHR35806; PTHR35806; 1.
DR   Pfam; PF03977; OAD_beta; 1.
DR   PIRSF; PIRSF015658; MmdB_OadB; 1.
DR   TIGRFAMs; TIGR01109; Na_pump_decarbB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Translocase; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..433
FT                   /note="Probable oxaloacetate decarboxylase beta chain"
FT                   /id="PRO_0000218567"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   433 AA;  45599 MW;  57AFA12E5B9B62C8 CRC64;
     MENILAMVRD FGLFHLQWGQ GIMILVGLVL LYLAIVKRFE PLLLVPIGFG GILSNLPDAG
     LAMSAIENAV YAAKPEVMTA FSEVLQLSSY MPADIKQALS SATPLQMTTL HLLAEQYQYS
     DGMLYLFYSI AIASGAGPLI IFMGVGAMTD FGPLLANPKT LLLGAAAQFG IFTTVLGALA
     LSSLGVMDFS VAQAAAIGII GGADGPTAIY VSSMLAPELL GAIAVAAYSY MALVPMIQPP
     IMRALTTQEE RKIQMQQLRQ VHKLEKIGFP LLLLILIALL LPSATPLLGM FCFGNLMREC
     GVVERLSDTA QNALINIVTI FLGLSVGSKL MADKFLQPQT IGILVLGIVA FCVGTAAGVL
     MAKLMNRFST TKLNPLIGSA GVSAVPMAAR VSNKVGLEAN AQNFLLMHAM GPNVAGVIGS
     AVAAGVMIKY VMG