ID   A26_VAR67               Reviewed;         498 AA.
AC   Q89489;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 67.
DE   RecName: Full=Protein A26 homolog;
GN   Name=A29L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967;
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967;
RX   PubMed=7856312; DOI=10.1016/0168-1702(94)90125-2;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V., Olenina L.V.,
RA   Chirikova G.B., Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of 53 kbp from the right terminus of
RT   the genome of variola major virus strain India-1967.";
RL   Virus Res. 34:207-236(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967;
RX   PubMed=7597802; DOI=10.1007/bf01702879;
RA   Shchelkunov S.N., Totmenin A.V.;
RT   "Two types of deletions in orthopoxvirus genomes.";
RL   Virus Genes 9:231-245(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967;
RX   PubMed=8725113; DOI=10.1016/0168-1702(95)01269-9;
RA   Shchelkunov S.N., Totmenin A.V., Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of 23.8 kbp from the left terminus of
RT   the genome of variola major virus strain India-1967.";
RL   Virus Res. 40:169-183(1996).
CC   -!- FUNCTION: Plays a role in bridging the mature virion with structural
CC       protein A25. Presence of protein A26 in the virion structurally
CC       prevents direct virus-cell fusion mechanism.
CC   -!- SUBUNIT: Interacts with proteins A17, A25 and A27. Interacts with host
CC       laminin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane. Note=A26 is anchored to the
CC       mature virion (MV) membrane through disulfide bonding with protein A27.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A26 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X69198; CAA49074.1; -; Genomic_DNA.
DR   PIR; C36851; C36851.
DR   RefSeq; NP_042177.1; NC_001611.1.
DR   SMR; Q89489; -.
DR   PRIDE; Q89489; -.
DR   GeneID; 1486505; -.
DR   KEGG; vg:1486505; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009285; Orthopox_A30L/A26L.
DR   Pfam; PF06086; Pox_A30L_A26L; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Reference proteome; Virion.
FT   CHAIN           1..498
FT                   /note="Protein A26 homolog"
FT                   /id="PRO_0000412610"
FT   REGION          352..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..378
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        43..342
FT                   /evidence="ECO:0000250"
FT   DISULFID        439
FT                   /note="Interchain (with C-71 in A27)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        440
FT                   /note="Interchain (with C-72 in A27)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   498 AA;  57976 MW;  E49BEF3C13AC08AD CRC64;
     MVNIINLWNG IVPMVQDVNV ASITAFKSMI DETWDKKIEA NTCISRKHRN IIHEVIRDFM
     KAYPKMDENR KSPLGAPMQW LTQYYILKNE YYKTMLAYDN ESLNTKFKTL NIYMITNVGQ
     YILYIVFCII SGKNHNGTPY IYDSEITSNN KNLINDRIKY ACKQILHGQL TMALRIRNKF
     MFIGSPMYLW FNVNGSHVYH EIYDGNVGFH NKEIGRLLYA FMYYLSISDR FLNDFALLKF
     TYLGESWTFS LSVPEYILYG LGYSVFDTIE KFSNDAILVY IKTNNRNGYD YVEFNKKGIV
     KVTETKPDND KRIHAIRLIN NSTDVQHIHF GFRNMVIIDN ECANIQSSVE NATDTGHHQD
     SKINIKDDDV DDDDYNPKPT PIPEPYPRPP FPRHEYYKRP KLLHVEEPDP VKKDADRIRL
     DNHILNTLDH NLNSIGHYCC DTAAVDRLEH HIETLGQYAV ILARKINMQS LLFPWLLPTV
     HPHAIDGSIP PHGRSTIL