OADG_KLEPN
ID OADG_KLEPN Reviewed; 83 AA.
AC P13155;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Oxaloacetate decarboxylase gamma chain;
DE EC=7.2.4.2;
GN Name=oadG;
OS Klebsiella pneumoniae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=2549031; DOI=10.1016/s0021-9258(18)63756-1;
RA Laussermair E., Schwarz E., Oesterhelt D., Reinke H., Beyreuther K.,
RA Dimroth P.;
RT "The sodium ion translocating oxaloacetate decarboxylase of Klebsiella
RT pneumoniae. Sequence of the integral membrane-bound subunits beta and
RT gamma.";
RL J. Biol. Chem. 264:14710-14715(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 13882 / NBRC 13541 / NCTC 8172;
RX PubMed=1577734; DOI=10.1016/s0021-9258(19)50375-1;
RA van der Rest M.E., Siewe R.M., Abee T., Schwarz E., Oesterhelt D.,
RA Konings W.N.;
RT "Nucleotide sequence and functional properties of a sodium-dependent
RT citrate transport system from Klebsiella pneumoniae.";
RL J. Biol. Chem. 267:8971-8976(1992).
CC -!- FUNCTION: Catalyzes the decarboxylation of oxaloacetate coupled to
CC Na(+) translocation.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) +
CC pyruvate; Xref=Rhea:RHEA:57724, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16526, ChEBI:CHEBI:29101; EC=7.2.4.2;
CC -!- COFACTOR:
CC Name=Na(+); Xref=ChEBI:CHEBI:29101;
CC -!- SUBUNIT: Heterotrimer of an alpha, a beta and a gamma subunit.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC -!- SIMILARITY: Belongs to the OadG family. {ECO:0000305}.
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DR EMBL; M26289; AAA25117.1; -; Genomic_DNA.
DR EMBL; M83146; AAA25061.1; -; Genomic_DNA.
DR PIR; A36505; A36505.
DR RefSeq; WP_004151376.1; NZ_WXZY01000006.1.
DR AlphaFoldDB; P13155; -.
DR SMR; P13155; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015451; F:decarboxylation-driven active transmembrane transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR HAMAP; MF_00404; OadG; 1.
DR InterPro; IPR005899; Na_pump_deCOase.
DR InterPro; IPR023424; OadG.
DR Pfam; PF04277; OAD_gamma; 1.
DR TIGRFAMs; TIGR01195; oadG_fam; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; Ion transport; Membrane; Sodium;
KW Sodium transport; Translocase; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..83
FT /note="Oxaloacetate decarboxylase gamma chain"
FT /id="PRO_0000216451"
FT TRANSMEM 11..33
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 83 AA; 8909 MW; 493A5B564975591D CRC64;
MTDNAVLLGE GFTLMCLGMG FVLVFLLLLI FAIRGMSLAV NRLFPEPPAA PKPAPAAVAP
ADDFARLKPA IVAAIHHHRR LHP