ID   OAF3_ASHGO              Reviewed;         795 AA.
AC   Q75BN0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Oleate activated transcription factor 3;
GN   Name=OAF3; OrderedLocusNames=ACR241C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC       number of target genes in response to oleate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR   EMBL; AE016816; AAS51467.2; -; Genomic_DNA.
DR   RefSeq; NP_983643.2; NM_208996.2.
DR   AlphaFoldDB; Q75BN0; -.
DR   SMR; Q75BN0; -.
DR   STRING; 33169.AAS51467; -.
DR   EnsemblFungi; AAS51467; AAS51467; AGOS_ACR241C.
DR   GeneID; 4619775; -.
DR   KEGG; ago:AGOS_ACR241C; -.
DR   eggNOG; ENOG502QQCV; Eukaryota.
DR   HOGENOM; CLU_018684_0_0_1; -.
DR   InParanoid; Q75BN0; -.
DR   OMA; WCAPEDG; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc.
FT   CHAIN           1..795
FT                   /note="Oleate activated transcription factor 3"
FT                   /id="PRO_0000409037"
FT   DNA_BIND        14..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   795 AA;  90678 MW;  CAD30CF6176A5D82 CRC64;
     MMPLKKRQRQ TLVCSNCKRR KSRCDRGKPA CGNCIRLGNR ETCHYFISPS EKGGDGGDSP
     GESAGSNGAL ERWQFVRAHS CGRVDLTAGR TVVFGKRSAV YVAGVLSTDA VRYRDLYLEL
     LSVFSHAAIK KTVSQLHAQA QVGAQEASLP NSVKRVIRME DEGMLQESSP YILAKHKKVH
     QSLVDGFAQS RYEGRQQFAD VEEAAKQHLV ERYIFLQKVL PAFKKHVLPL IPIYDERMLC
     VTVEQLYDDY QKRGKFSAKN GDLITVATIL LITRLVYLAI RFDKCSVVNV KYNRILELDT
     EPYAALAYEL LPRDKLLRKV TLPQLQCLIL LRFHNWCSPM DGDGESLQYS NVLMGTIYAC
     CKEIGASWLS FKEPDKYDFA KARGSNSRFT MAFAEMEPGE VDSANESVVK LYQQIWAVVL
     HWDRNVSMLT GLEPIIGTSM KPAAMSSYNN WYADMISLDY LKWQLLTRIN EDPSEVNLEE
     VKPIISEIRQ RLGQFTSESE LAFEQELILQ LVELSILHAA FIGPTSNVSA AEHRKNYQEL
     LERIIHLSGI FITYFHDPPT TNHQYGRFYT NKIVEVAMYR VYQILTGLIL RISSACQDQS
     LKPTLMKFYK NLCSLYFNEL GYDYYQVFKR LFEAKVKYKI LEQTANPVFI MLRYLFAEIQ
     SGNMESMKSQ ELIGLIYGEY KKMGGELNLD MMDLWNHIVP TQCDHNIGLN SLFTTEIFPT
     DQYSDYNLFV SFYDYASNKL TEDTNQAAEK SIAHNPSTSI HDLCKGGASP HFDLLEGILD
     PLDFMTYLDS IPGET