ID   OAF3_KLULA              Reviewed;         657 AA.
AC   Q6CXS0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Oleate activated transcription factor 3;
GN   Name=OAF3; OrderedLocusNames=KLLA0A06039g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC       number of target genes in response to oleate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH02857.1; -; Genomic_DNA.
DR   RefSeq; XP_451269.1; XM_451269.1.
DR   AlphaFoldDB; Q6CXS0; -.
DR   SMR; Q6CXS0; -.
DR   STRING; 28985.XP_451269.1; -.
DR   EnsemblFungi; CAH02857; CAH02857; KLLA0_A06039g.
DR   GeneID; 2896452; -.
DR   KEGG; kla:KLLA0_A06039g; -.
DR   eggNOG; ENOG502QQCV; Eukaryota.
DR   HOGENOM; CLU_018684_0_0_1; -.
DR   InParanoid; Q6CXS0; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc.
FT   CHAIN           1..657
FT                   /note="Oleate activated transcription factor 3"
FT                   /id="PRO_0000409039"
FT   DNA_BIND        21..48
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   657 AA;  77003 MW;  411F4D3ABB2D3BDA CRC64;
     MVYEMLSPVP VKKRHRPTLV CLNCRRRKTK CDRGKPSCSN CLKLGETCVY SEDTDENASK
     KVRYEYMDDL GLPEFINMAP KGLHLLSKRS ASWFNGLFSD IAICDRDPYL RITNAVIDIL
     RKSASKGIDR SERDTVLQLP NSLKTVTMYN RSEKSEDQLY HQIAREFSAL RSAPIPETYV
     PYEYEFWSKY YPYFVDKIHP LVPVFNLIEL KDLLEKFFQR QKDHPGKLND KVHESTLLML
     TYLIINFFLL EFDSHNRLIQ DHINIIKKWL VQSKWFQKTT LLQLRVWLVL RFHNWCTYHD
     NDGNRMNAND GLMGLIMGHC ASLGITWQLW TNVDSDECKN IWINALHWDR KLAVLNGNDT
     FNGRTMRVPE LPNDHLVLKF LKCCVDDPTH VNYKLAIEIL NKLNFEEQNP MVTWEWKVIV
     AVTKLQINHG RLNHINEGIS AVIASLEDLI TLWNEHFIRP LAPVSYSSRI IEISMNKALV
     LLPAIILRAR NPCKQKILQL MDKILTTYFN EFPYYYHVFK RLFKYKLTLN LINREDSLDH
     MLTILKHENH QVLEKLGITS KDAEMSDDDV IKVWNARFSF TEKVVNLKVE MMCKNYEPNL
     FSSSYQHALE KLEERHSAKA DAIDVTQFLQ QVFDSTDFDL FYGMDVGELP KMDSILP