ID   OAF3_LACTC              Reviewed;         802 AA.
AC   C5DKJ7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Oleate activated transcription factor 3;
GN   Name=OAF3; OrderedLocusNames=KLTH0F05258g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC       number of target genes in response to oleate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR   EMBL; CU928170; CAR23998.1; -; Genomic_DNA.
DR   RefSeq; XP_002554435.1; XM_002554389.1.
DR   AlphaFoldDB; C5DKJ7; -.
DR   SMR; C5DKJ7; -.
DR   STRING; 559295.C5DKJ7; -.
DR   EnsemblFungi; CAR23998; CAR23998; KLTH0F05258g.
DR   GeneID; 8292633; -.
DR   KEGG; lth:KLTH0F05258g; -.
DR   eggNOG; ENOG502QQCV; Eukaryota.
DR   HOGENOM; CLU_018684_0_0_1; -.
DR   InParanoid; C5DKJ7; -.
DR   OMA; WCAPEDG; -.
DR   OrthoDB; 622960at2759; -.
DR   Proteomes; UP000002036; Chromosome F.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc.
FT   CHAIN           1..802
FT                   /note="Oleate activated transcription factor 3"
FT                   /id="PRO_0000409040"
FT   DNA_BIND        22..51
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   802 AA;  90926 MW;  02565E13137D6985 CRC64;
     MEQDRASDVP PAKKRRRPTV VCTNCKRRKS KCDRLKPVCG NCLRLGDETT CAYGLEPAGE
     ARKPGVSRLV AQCFEMVRST QPTLIDLQPN GVLIQCKRSC TSYIAPLTPS AAKQRDPYLQ
     ALGLVCQLKR TMRAADPAPK KEGTAEATSR GSLPNSMRYI ESIEQNSPEQ PASLASRHKN
     MCRQLFTKFG KYRRNHTSST EDDLKALPSR VPAKKVFFRH IWPYFWSHLS GLCPIFDEAQ
     LEKSLKRVYD RFSPDTHSKL DVEDYACFSI VLLITCLVQL SLKFAQDYTE ENTNSESSIV
     MGIDTSKFIS MVNGCISRKK GDRKCSLLRL QSLLLLRFYY WCAPDDGDGD YLQHSNMLMG
     KIVAACYSMG IEWQCVRDPE EFVNNFNLCL GLMPLEAEYD ASDYKKIWTT VLHWDRKLSL
     LTGQRCLIGN SIKLPTPGHE SPSCALLKFD SLILKICDMI SNDPRRVDAT AVIRLLETLR
     QSLKKDTREN IVNPALGFEW GMVIALLELT ITHAHMVHSE KTESPDEFCD CIQGLFEKVL
     QITKICEQYL YSQEGLDPSA RFYTNKIVDI AFSSISAIFP SLILRSGRSI EPHTKTTLLN
     FYRDILSASF NTIGVEYYSC FRRMFPSKLV FRTLSAAGDE DPWTRILEFI VSSDYNKEFA
     LLQRSGIFKQ FFKSYEKTGN VESAASLWSA YYAPNDLYSF DLDVKSFGLQ MPFSHSNRYN
     DYDVFEAFFN NAKTLFLAKV PNLPALNGTA LGQGAFNYFD YSLLQGIENF DSADFLDFFE
     PGGSEALVEL ESQESPSNHD IC