ID   OAF3_VANPO              Reviewed;         802 AA.
AC   A7TGQ2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Oleate activated transcription factor 3;
GN   Name=OAF3; ORFNames=Kpol_2001p16;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC       number of target genes in response to oleate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR   EMBL; DS480388; EDO18515.1; -; Genomic_DNA.
DR   RefSeq; XP_001646373.1; XM_001646323.1.
DR   AlphaFoldDB; A7TGQ2; -.
DR   SMR; A7TGQ2; -.
DR   STRING; 436907.A7TGQ2; -.
DR   EnsemblFungi; EDO18515; EDO18515; Kpol_2001p16.
DR   GeneID; 5546805; -.
DR   KEGG; vpo:Kpol_2001p16; -.
DR   eggNOG; ENOG502QQCV; Eukaryota.
DR   HOGENOM; CLU_018684_0_0_1; -.
DR   InParanoid; A7TGQ2; -.
DR   OMA; WCAPEDG; -.
DR   OrthoDB; 622960at2759; -.
DR   PhylomeDB; A7TGQ2; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc.
FT   CHAIN           1..802
FT                   /note="Oleate activated transcription factor 3"
FT                   /id="PRO_0000409041"
FT   DNA_BIND        19..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          749..779
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        749..777
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   802 AA;  92245 MW;  D61135B19513AFF5 CRC64;
     MDMNENKVRK KRHRITVVCT NCKKRKSKCD RGKPCSNCTR IGIENSCLYI KDTPSLPIDS
     IGSVADLTAS ELQIPNFIPI HPSYNKEYVN YIPNGRFFEI KRSAYTMFPI FTDACIEHRD
     AVIKAFTTFR TIVVKKTIDH YRKTGIDIER IALAGSQGLP KSFLPLTVFD EESSKNLVLE
     QQEPQQSYQI HSLLAEKFSH YRKNANLKLG DDSTTVYHNL IIKSLPDLGL LMDTIIPYYE
     QFIEPLVPII EFKDFNVEIQ KLYAKIELSN SLDPKIGENT LACIILLICR LCHLSSKFAV
     EKSINSSNYE SILNMDTNIF VSLVQRTATG EKPLRKGTLY ELQLLIMLRL CYWVGPDDGD
     GQQVEQSEIL HGAIVSMCKH MGVWWDLVKY SEDSDLFITV DYKAVPKLGS QSEYIKLFRK
     IWCYVLCWDR KMMLLTGQEC EIGRSYKMSP APRFGNGWCD DILQYDYLLY GINNELHDDA
     RKVDISMLEE LVEMSEMRMG VLKEDDFSSN IYREQKLSLM LMKLNIIHGQ LSWYERTGDK
     QSQETAYAKL FTLTVELGSK CVEYFSTPGI PEQRFYMNKI YEVILNRLNN VIVPGLILRI
     RYEEETGLDG MVKYLYGMSS MYFNEIGKEY YRTFKKMFHG KINYKILENG HRCMDMIIKF
     LQREMQNNND TAVSKGDSMK LSDRLPLVAW DSNSTNDMFE PIHTVPRGPE IAALILEMVN
     VSDRYHYNNN VFQTVYKEAR LVIDETTTTS QQDSLASAGT NRTNNIATNS GSGDDGGNGS
     DDSYLMRLIQ ELFDPLDFAS AF