ID   OAF3_YEAS1              Reviewed;         863 AA.
AC   B3LRD9;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Oleate activated transcription factor 3;
GN   Name=OAF3; ORFNames=SCRG_04079;
OS   Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=285006;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM11-1a;
RG   The Broad Institute Genome Sequencing Platform;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Cuomo C.,
RA   Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA   Mauceli E.W., Brockman W., MacCallum I.A., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   O'Leary S., Kodira C.D., Zeng Q., Yandava C., Alvarado L., Pratt S.,
RA   Kruglyak L.;
RT   "Annotation of the Saccharomyces cerevisiae RM11-1a genome.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC       number of target genes in response to oleate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR   EMBL; CH408051; EDV13142.1; -; Genomic_DNA.
DR   AlphaFoldDB; B3LRD9; -.
DR   SMR; B3LRD9; -.
DR   EnsemblFungi; EDV13142; EDV13142; SCRG_04079.
DR   HOGENOM; CLU_018684_0_0_1; -.
DR   Proteomes; UP000008335; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus; Repressor;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..863
FT                   /note="Oleate activated transcription factor 3"
FT                   /id="PRO_0000409042"
FT   DNA_BIND        19..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          52..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   863 AA;  101906 MW;  DD1FA79689B4A294 CRC64;
     MGYDSQVRTK KRHRITVVCT NCKKRKSKCD RTKPCGTCVR LGDVDSCVYL TDSSGQPESS
     PSLNDADPLR KQSTPAERIS PGFIKKRRSS QTRQDEDHWQ RVRELESQSS LYYLPIHEET
     PFFIDLIPNG FYLETKRSAD NLFGLFTDRA IENRDPYLQA MVTFRSIAIK KMMDKLGSNG
     NNVKNGSLPK SFEALSTFDA DDERHISDDV VDKGNNFRMH QTIHKSLFNK FAQYRENNAK
     KFSSETILAK DYLPPLKILE SEVLALFEEK IYNMIPIFDM KILRHEITIF YQNIVEKGNP
     ISIKHYDHMV FCIILLIIKI CRLSVQFSKL TPYIYPVLQE IDTSKFLALV KHYLFETKVL
     RKCNFLQLQC LILLRFLHWC APEDGDGPET QYCQILMGTI ISSCKEMGIN WYCFSHPEKY
     SFKINRHTRP SYDIMKPSDY ISVFRKIWSY VLFWDRKMCF ISGEECQIGK TLQCHFKEEA
     DTPTWYIRML TLDNLMKKIN DTLNDDPGKV DLNLLHRLIN DLKRNFHILK SLSKNEKETM
     RHFDFEMEWI IDLFSLSLLH GEMIFYEYDC NITKFYKSFQ DLWDMVIHIS EKCYNYFFNS
     DALEVDSLTK FYTNRIVEIV ANKVLVIVPA FILRGDRFKT IQYADKKKMI EFLYGVSSVY
     FNEFGFEYYR CFRKMFTAKI AYKILNRSCE KDAWRIILKF LLNELKLEDN GDSYIDYNDM
     RLKDICPIIL EFQETVQKYD GYRPDILSIW NNEFYPIGKY NDDMTGFKFQ MRIKEMQEFL
     DMEKYSDRFN IFSSFYDHAS SQLAKHTEVD TNISITNEQV AETPQKELLQ QPLAPALPVN
     DLIVSEFDVI EDIFDPVDFV SFF