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OAF3_YEAS2
ID   OAF3_YEAS2              Reviewed;         861 AA.
AC   C7GX75;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Oleate activated transcription factor 3;
GN   Name=OAF3; ORFNames=C1Q_05113;
OS   Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=574961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAY291;
RX   PubMed=19812109; DOI=10.1101/gr.091777.109;
RA   Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M., Netto O.V.C.,
RA   Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O., Noronha M.F.,
RA   Dominska M., Andrietta M.G.S., Andrietta S.R., Cunha A.F., Gomes L.H.,
RA   Tavares F.C.A., Alcarde A.R., Dietrich F.S., McCusker J.H., Petes T.D.,
RA   Pereira G.A.G.;
RT   "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT   bioethanol production.";
RL   Genome Res. 19:2258-2270(2009).
CC   -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC       number of target genes in response to oleate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR   EMBL; ACFL01000410; EEU04592.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7GX75; -.
DR   SMR; C7GX75; -.
DR   Proteomes; UP000008073; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus; Repressor;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..861
FT                   /note="Oleate activated transcription factor 3"
FT                   /id="PRO_0000409043"
FT   DNA_BIND        19..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          52..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..99
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   861 AA;  101530 MW;  23AC0BAC106FE116 CRC64;
     MTPKLGQKKR HRITVVCTNC KKRKSKCDRT KPCGTCVRLG DVDSCVYLID SSGQPESSPS
     LNDADPLRKQ STPAERISPG FIKKRRSSQT RQDEDHWQRV RELESQSSLY YLPIHEETPF
     FIDLIPNGFY LETKRSADNL FGLFSDRAIE NRDPYLQAMV TFRSIAIKKM MDKLGSNGNN
     VKNGSLPKSF EALSTFDADD ERHISDDVVD KGNNCRMHQT IHKSLFNKFA QYRENNAKKF
     SSETILAKDY LPPLKILESE VLALFEEKIY NMIPIFDMKI LRHEITIFYQ NIVEKGNPIS
     IKHYDHMVFC IILLIIKICR LSVQFSKLTP YIYPVLQEID TSKFLALVKH YLFETKVLRK
     CNLLQLQCLI LLRFLHWCAP EDGDGPETQY CQILMGTIIS SCKEMGINWY CFSHPEKYSF
     KINRHTRPSY DIMKPSDYIS VFRKIWSYVL FWDRKMCFIS GEECQIGKTL QCHFKEEADT
     PTWYIRMLTL DNLMKKINDT LNDDPGKVDL NLLHRLINDL KRNFHILKSL SKNEKETMRH
     FDFEMEWIID LFSLSLLHGE MIFYEYDCNI TKFYKSFQDL WDMVIHISEK CYNYFFNSDA
     LEVDSLTKFY TNRIVEIVAN KVLVIVPAFI LRGDRFKTIQ YADKKKMIEF LYGVSSVYFN
     EFGFEYYRCF RKMFTAKIAY KILNRSCEKD AWRIILNFLL NELKLEDNGD SYIDYNDMRL
     KDICPIILEF QETVQKYDGY RPDILSIWNN EFYPIGKYND DMTGFKFQMR IKEMQEFLDM
     EKYSDRFNIF SSFYDHASSQ LAKHTEVDTN ISITNEQVAE TPQKELLQQP LAPALPVNDL
     IVSEFDVIED IFDPVDFVSF F
 
 
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