OAF3_YEAS2
ID OAF3_YEAS2 Reviewed; 861 AA.
AC C7GX75;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Oleate activated transcription factor 3;
GN Name=OAF3; ORFNames=C1Q_05113;
OS Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=574961;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAY291;
RX PubMed=19812109; DOI=10.1101/gr.091777.109;
RA Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M., Netto O.V.C.,
RA Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O., Noronha M.F.,
RA Dominska M., Andrietta M.G.S., Andrietta S.R., Cunha A.F., Gomes L.H.,
RA Tavares F.C.A., Alcarde A.R., Dietrich F.S., McCusker J.H., Petes T.D.,
RA Pereira G.A.G.;
RT "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT bioethanol production.";
RL Genome Res. 19:2258-2270(2009).
CC -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC number of target genes in response to oleate. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR EMBL; ACFL01000410; EEU04592.1; -; Genomic_DNA.
DR AlphaFoldDB; C7GX75; -.
DR SMR; C7GX75; -.
DR Proteomes; UP000008073; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus; Repressor;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..861
FT /note="Oleate activated transcription factor 3"
FT /id="PRO_0000409043"
FT DNA_BIND 19..47
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 52..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 101530 MW; 23AC0BAC106FE116 CRC64;
MTPKLGQKKR HRITVVCTNC KKRKSKCDRT KPCGTCVRLG DVDSCVYLID SSGQPESSPS
LNDADPLRKQ STPAERISPG FIKKRRSSQT RQDEDHWQRV RELESQSSLY YLPIHEETPF
FIDLIPNGFY LETKRSADNL FGLFSDRAIE NRDPYLQAMV TFRSIAIKKM MDKLGSNGNN
VKNGSLPKSF EALSTFDADD ERHISDDVVD KGNNCRMHQT IHKSLFNKFA QYRENNAKKF
SSETILAKDY LPPLKILESE VLALFEEKIY NMIPIFDMKI LRHEITIFYQ NIVEKGNPIS
IKHYDHMVFC IILLIIKICR LSVQFSKLTP YIYPVLQEID TSKFLALVKH YLFETKVLRK
CNLLQLQCLI LLRFLHWCAP EDGDGPETQY CQILMGTIIS SCKEMGINWY CFSHPEKYSF
KINRHTRPSY DIMKPSDYIS VFRKIWSYVL FWDRKMCFIS GEECQIGKTL QCHFKEEADT
PTWYIRMLTL DNLMKKINDT LNDDPGKVDL NLLHRLINDL KRNFHILKSL SKNEKETMRH
FDFEMEWIID LFSLSLLHGE MIFYEYDCNI TKFYKSFQDL WDMVIHISEK CYNYFFNSDA
LEVDSLTKFY TNRIVEIVAN KVLVIVPAFI LRGDRFKTIQ YADKKKMIEF LYGVSSVYFN
EFGFEYYRCF RKMFTAKIAY KILNRSCEKD AWRIILNFLL NELKLEDNGD SYIDYNDMRL
KDICPIILEF QETVQKYDGY RPDILSIWNN EFYPIGKYND DMTGFKFQMR IKEMQEFLDM
EKYSDRFNIF SSFYDHASSQ LAKHTEVDTN ISITNEQVAE TPQKELLQQP LAPALPVNDL
IVSEFDVIED IFDPVDFVSF F