ID   OAF3_YEAS7              Reviewed;         863 AA.
AC   A7A024;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Oleate activated transcription factor 3;
GN   Name=OAF3; ORFNames=SCY_3434;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Transcriptional inhibitor with a significantly increased
CC       number of target genes in response to oleate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00227}. Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OAF3 family. {ECO:0000305}.
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DR   EMBL; AAFW02000152; EDN59967.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7A024; -.
DR   EnsemblFungi; EDN59967; EDN59967; SCY_3434.
DR   HOGENOM; CLU_018684_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Metal-binding; Mitochondrion; Nucleus; Repressor;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..863
FT                   /note="Oleate activated transcription factor 3"
FT                   /id="PRO_0000409045"
FT   DNA_BIND        19..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          52..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..99
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   863 AA;  101887 MW;  A0972DA3770F2399 CRC64;
     MGYDSQVRTK KRHRITVVCT NCKKRKSKCD RTKPCGTCVR LGDVDSCVYL TDSSGQPESS
     PSLNDADPLR KQSTPAERIS PGFIKKRRSS QTRQDEDHWQ RVRELENQSS LYYLPIHEET
     PFFIDLIPSG FYLETKRSAD NLFGLFTDRA IENRDPYLQT MVTFRSIAIK KMMDKLGSNG
     NNVKNGSLPK SFEALSTFDA DDERHISDDV VDKGNNFRMH QTIHKSLFNK FAQYRENNAK
     KFSSETILAK DYLPPLKILE SEVLALFEEK IYNMIPIFDM KILRHEITIF YQNIVEKGNP
     VSIKHYDHMV FCIILLIIKI CRLSVQFSKL TPYIYPVLQE IDTSKFLALV KHYLFETKVL
     RKCNLLQLQC LILLRFLHWC APEDGDGPET QYCQILMGTI ISSCKEMGIN WYCFSHPEKY
     SFKINRHTRP SYDIMKPSDY ISVFRKIWSY VLFWDRKMCF ISGEECQIGK TLQCHFKEEA
     DTPTWYIRML TLDNLMKKIN DTLNDDPGKV DLNLLHRLIN DLKRNFHILK SLSKNEKETM
     RHFDFEMEWI IDLFSLSLLH GEMIFYEYDC NITKFYKSFQ DLWDMVIHIS EKCYNYFFNS
     DALEVDSLTK FYTNRIVEIV ANKVLVIVPA FILRGDRFKT IQYADKKKMI EFLYGVSSVY
     FNEFGFEYYR CFRKMFTAKI AYKILNRSCE KNAWRIILKF LLNELKLEDN GDSYIDYNDM
     RLKDICPIIL EFQETVQKYD GYRPDILSIW NNEFYPIGKY NDDMTGFKFQ MRIKEMQEFL
     DMEKYSDRFN IFSSFYDHAS SQLAKHTEVD TNISITNEQV AETPQKELLQ QPLAPALPVN
     DLIVSEFDVI EDIFDPVDFV SFF