ID   ARRC_BOVIN              Reviewed;         389 AA.
AC   Q9N0H5;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Arrestin-C;
DE   AltName: Full=Cone arrestin;
DE            Short=cArr;
DE   AltName: Full=Retinal cone arrestin-3;
DE   AltName: Full=X-arrestin;
GN   Name=ARR3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Retina;
RX   PubMed=10745092; DOI=10.1016/s0014-5793(00)01334-x;
RA   Maeda T., Ohguro H., Sohma H., Kuroki Y., Wada H., Okisaka S., Murakami A.;
RT   "Purification and characterization of bovine cone arrestin (cArr).";
RL   FEBS Lett. 470:336-340(2000).
RN   [2]
RP   SUBUNIT, AND TISSUE SPECIFICITY.
RX   PubMed=25772009; DOI=10.1016/j.freeradbiomed.2015.03.001;
RA   Zernii E.Y., Nazipova A.A., Gancharova O.S., Kazakov A.S.,
RA   Serebryakova M.V., Zinchenko D.V., Tikhomirova N.K., Senin I.I.,
RA   Philippov P.P., Permyakov E.A., Permyakov S.E.;
RT   "Light-induced disulfide dimerization of recoverin under ex vivo and in
RT   vivo conditions.";
RL   Free Radic. Biol. Med. 83:283-295(2015).
CC   -!- FUNCTION: May play a role in an as yet undefined retina-specific signal
CC       transduction. Could bind to photoactivated-phosphorylated red/green
CC       opsins.
CC   -!- SUBUNIT: Homodimer; disulfide-linked in response to retinal
CC       illumination (PubMed:25772009). Interacts with CXCR4; the interaction
CC       is dependent on the C-terminal phosphorylation of CXCR4 and modulates
CC       the calcium ion mobilization activity of CXCR4 (By similarity).
CC       {ECO:0000250|UniProtKB:P36575, ECO:0000269|PubMed:25772009}.
CC   -!- SUBCELLULAR LOCATION: Photoreceptor inner segment
CC       {ECO:0000250|UniProtKB:Q9EQP6}. Cell projection, cilium, photoreceptor
CC       outer segment {ECO:0000250|UniProtKB:Q9EQP6}.
CC   -!- TISSUE SPECIFICITY: Expressed in cone photoreceptors in the retina (at
CC       protein level). {ECO:0000269|PubMed:10745092,
CC       ECO:0000269|PubMed:25772009}.
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA94344.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D85340; BAA94344.1; ALT_INIT; mRNA.
DR   RefSeq; NP_776419.1; NM_173994.2.
DR   AlphaFoldDB; Q9N0H5; -.
DR   SMR; Q9N0H5; -.
DR   STRING; 9913.ENSBTAP00000017088; -.
DR   PaxDb; Q9N0H5; -.
DR   PRIDE; Q9N0H5; -.
DR   GeneID; 281011; -.
DR   KEGG; bta:281011; -.
DR   CTD; 407; -.
DR   eggNOG; KOG3865; Eukaryota.
DR   InParanoid; Q9N0H5; -.
DR   OrthoDB; 783081at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0002031; P:G protein-coupled receptor internalization; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 1.
DR   Gene3D; 2.60.40.840; -; 1.
DR   InterPro; IPR033042; ARR3.
DR   InterPro; IPR000698; Arrestin.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR017864; Arrestin_CS.
DR   InterPro; IPR014753; Arrestin_N.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11792; PTHR11792; 1.
DR   PANTHER; PTHR11792:SF19; PTHR11792:SF19; 1.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; SSF81296; 2.
DR   PROSITE; PS00295; ARRESTINS; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Disulfide bond; Reference proteome; Sensory transduction;
KW   Vision.
FT   CHAIN           1..389
FT                   /note="Arrestin-C"
FT                   /id="PRO_0000250486"
FT   REGION          369..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   389 AA;  42880 MW;  4311122C27AF716E CRC64;
     MSRVFKKTCS NGKLSIYLGK RDFVDHVDMV EPIDGVVLVD PEYLKGRKMF VMLTCAFRYG
     HDDLDVIGLT FRKDLYVQVQ QVVPAESSSP RGSLTVLQER LLHKLGDNAY PFTLQMVVNL
     PCSVTLQPGP DDTGKACGVD FEVKSFCAEN LEEKVSKRDS VRLVIRKIQF APLEPGPGPW
     ARLCRRFLLS AQPLLLQAWM DKEVNYHGQP ISVNVSINNS TNKVIKKIKI SVDQITDVVL
     YSLDKYTKTV FVQEFTETIA ANSTFSKSFA VTPLLADNCH KQGLALDGKL KQGDTNLASS
     TILRPGVDKE LLGILVSYKV RVNLMVSCEG ILGDLTASEV GVELPLILMH PKPSNEAASS
     EDIVIEEFAQ QEPSGESQEA LAAEGNEGS